SARS-CoV-2 infection of human iPSC-derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19.

Science Translational Medicine
J. A. Perez-BermejoTodd C McDevitt

Abstract

Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell (iPSC)-derived heart cells to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. Transcriptomic disruption of structural genes corroborates adverse morphologic features, which included a distinct pattern of myofibrillar fragmentation and nuclear disruption. Human autopsy specimens from patients with COVID-19 reflected similar alterations, particularly sarcomeric fragmentation. These notable cytopathic features in cardiomyocytes provide insights into SARS-CoV-2-induced cardiac damage, offer a platform for discovery of potential therapeutics, and raise concerns about the long-term consequences of COVID-19 in asymptomatic and severe cases.

References

Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D Applegate, E Reisler
Oct 29, 2002·Journal of Clinical Pathology·P A J KrijnenH W M Niessen
Jul 27, 2005·The Journal of Experimental Medicine·Jiang GuAnthony S-Y Leong
May 21, 2009·European Journal of Clinical Investigation·G Y OuditJ Butany
Mar 27, 2010·Bioinformatics·Grégoire PauWolfgang Huber
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Mar 6, 2013·Nature Nanotechnology·Sanjay Kumar
Mar 13, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Sharlene M Day
Feb 4, 2014·Genome Biology·Charity W LawGordon K Smyth
Feb 11, 2014·Nature Methods·Yuichiro MiyaokaBruce R Conklin
Jul 16, 2014·PeerJ·Stéfan van der WaltUNKNOWN scikit-image contributors
Mar 10, 2015·Nature Methods·Daehwan KimSteven L Salzberg
Dec 15, 2015·Methods : a Companion to Methods in Enzymology·Tracy A HookwayTodd C McDevitt
Jun 17, 2016·Molecular Biology of the Cell·Alexander L Auld, Eric S Folker
Jun 7, 2018·Nature Reviews. Cardiology·Hisayuki HashimotoRhonda Bassel-Duby
May 16, 2019·Molecular Biology of the Cell·Rachel M StewartMegan C King
Jun 11, 2019·Cell·Tim StuartRahul Satija
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Mar 20, 2020·JAMA : the Journal of the American Medical Association·Matt ArentzMelissa Lee
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Apr 4, 2020·Circulation·Justin A FriedGabriel Sayer
Apr 11, 2020·European Journal of Heart Failure·Guido TavazziEloisa Arbustini
Apr 16, 2020·European Heart Journal·Luka NicinStefanie Dimmeler
Apr 16, 2020·Circulation·Peter P LiuHongliang Li
Apr 23, 2020·JAMA : the Journal of the American Medical Association·Safiya RichardsonTheodoros P Zanos
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
May 3, 2020·Science·Mart M LamersHans Clevers
May 15, 2020·Nature Medicine·Jie ZhouKwok Yung Yuen
May 18, 2020·Cell·Daniel Blanco-MeloBenjamin R tenOever
May 22, 2020·JAMA : the Journal of the American Medical Association·Tina SchallerRainer Claus
May 30, 2020·Pharmacology & Therapeutics·Tianxiao LiuGuo-Ping Shi
May 31, 2020·The Lancet. Respiratory Medicine·Sharon E FoxRichard S Vander Heide
Jun 9, 2020·BioRxiv : the Preprint Server for Biology·Yuling HanShuibing Chen
Jun 20, 2020·The European Respiratory Journal·Alice HuertasMarc Humbert

❮ Previous
Next ❯

Citations

Apr 1, 2021·Protein Science : a Publication of the Protein Society·Keval BollavaramManu O Platt
May 8, 2021·Proceedings of the National Academy of Sciences of the United States of America·Liguo ZhangRudolf Jaenisch
Jun 11, 2021·Nature·Elie Dolgin
Jun 22, 2021·ACS Biomaterials Science & Engineering·Diogo TelesGordana Vunjak-Novakovic
Jun 25, 2021·Circulation Research·Masataka Nishiga, Joseph C Wu

❮ Previous
Next ❯

Related Concepts