SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ahmad Ud DinJianbo Wu

Abstract

In December 2019, a pneumonia outbreak of unknown etiology was reported which caused panic in Wuhan city of central China, which was later identified as Coronavirus disease (COVID-19) caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by the Chinese Centre for Disease Control and Prevention (CDC) and WHO. To date, the SARS-CoV-2 spread has already become a global pandemic with a considerable death toll. The associated symptoms of the COVID-19 infection varied with increased inflammation as an everyday pathological basis. Among various other symptoms such as fever, cough, lethargy, gastrointestinal (GI) symptoms included diarrhea and IBD with colitis, have been reported. Currently, there is no sole cure for COVID-19, and researchers are actively engaged to search out appropriate treatment and develop a vaccine for its prevention. Antiviral for controlling viral load and corticosteroid therapy for reducing inflammation seems to be inadequate to control the fatality rate. Based on the available related literature, which documented GI symptoms with diarrhea, inflammatory bowel diseases (IBD) with colitis, and increased deaths in the intensive care unit (ICU), conclude that dysbiosis occurs d...Continue Reading

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Feb 13, 2021·International Journal of Environmental Research and Public Health·Lola Rueda RuzafaArik J Hone
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Clinical Trials Mentioned

NCT04390477
NCT04366180
NCT04458519
NCT04366089
NCT04462627
NCT04420676
NCT04399252
NCT04334980
NCT04368351
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