SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Kizzmekia S CorbettBarney S Graham


A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilize Betacoronavirus spike proteins in the prefusion state, improving their expression and increasing immunogenicity1. This principle has been applied to design mRNA-1273, an mRNA vaccine that encodes a SARS-CoV-2 spike protein that is stabilized in the prefusion conformation. Here we show that mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mutant2 SARS-CoV-2 as well as CD8+ T cell responses, and protects against SARS-CoV-2 infection in the lungs and noses of mice without evidence of immunopathology. mRNA-1273 is currently in a phase III trial to evaluate its efficacy.


Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Trevor ScobeyRalph S Baric
Jul 29, 2015·Nature Communications·Lingshu WangBarney S Graham
Nov 10, 2015·Nature Medicine·Vineet D MenacheryRalph S Baric
Mar 5, 2016·Nature·Robert N KirchdoerferAndrew B Ward
Mar 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Vineet D MenacheryRalph S Baric
Oct 7, 2016·Science·Kimberly A DowdBarney S Graham
Nov 29, 2016·Nature Microbiology·Adam S CockrellRalph S Baric
May 2, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kapil BahlGiuseppe Ciaramella
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jesper PallesenJason S McLellan
Dec 5, 2017·Nature Immunology·Barney S Graham, Nancy J Sullivan
Dec 26, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Annette B VogelJohn S Tregoning
Jan 13, 2018·Nature Reviews. Drug Discovery·Norbert PardiDrew Weissman
Mar 23, 2018·JAMA : the Journal of the American Medical Association·Barney S GrahamAnthony S Fauci
Jan 30, 2019·Annual Review of Medicine·Barney S GrahamJason S McLellan
Feb 21, 2019·Molecular Therapy. Nucleic Acids·Kimberly J HassettLuis A Brito
Aug 3, 2019·Science·Michelle C CrankUNKNOWN VRC 317 Study Team
Nov 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·David M MaugerIain J McFadyen
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Feb 23, 2020·The Lancet Infectious Diseases·Ensheng DongLauren Gardner
May 1, 2020·The Journal of Clinical Investigation·Barney S Graham, Kizzmekia S Corbett
May 10, 2020·Science·Barney S Graham
Jun 9, 2020·BioRxiv : the Preprint Server for Biology·Brandi FreemanNatalie J Thornburg
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Carleen Klumpp-ThomasKaitlyn Sadtler
Jun 24, 2020·Frontiers in Public Health·Raghuvir KeniKrishnadas Nandakumar
Jul 9, 2020·Science Advances·Jennifer NelsonJohn L Joyal
Aug 28, 2020·Nature·Kenneth H DinnonRalph S Baric

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Dec 1, 2020·Drug Development Research·Fatemeh BabaeiHossein Hosseinzadeh
Dec 10, 2020·Nature Biomedical Engineering·Norbert Pardi, Drew Weissman
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Jan 5, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nikoo Hossein-KhannazerMassoud Vosough
Jan 14, 2021·Journal of Biomedical Science·Ioannis P TrougakosMeletios A Dimopoulos
Dec 12, 2020·Cell Host & Microbe·Drew WeissmanDavid C Montefiori
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Nov 21, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vladislav IzdaAmr H Sawalha
Jan 23, 2021·Vaccines·Alberto Cagigi, Karin Loré
Feb 6, 2021·Scientific Reports·Inga SzurgotPeter Liljeström
Nov 10, 2020·Frontiers in Immunology·Omna SharmaChris R Triggle
Sep 25, 2020·Current Opinion in HIV and AIDS·Yihan WangDongming Zhou
Aug 25, 2020·Journal of Medical Virology·Ji-Ming Chen
Aug 28, 2020·Nature·Kenneth H DinnonRalph S Baric
Sep 6, 2020·Disease Models & Mechanisms·Sarah R LeistDavid R Martinez
Oct 2, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Hara JangSeung Jae Lee
Sep 6, 2020·Nature Reviews. Immunology·Mangalakumari JeyanathanZhou Xing
Jan 7, 2021·Military Medical Research·Dan-Dan Li, Qi-Han Li
Jan 9, 2021·Frontiers in Immunology·Jonas B Sandbrink, Robin J Shattock
Feb 18, 2021·Molecular Cancer·Yang WangXiawei Wei
Sep 30, 2020·The New England Journal of Medicine·Evan J AndersonUNKNOWN mRNA-1273 Study Group
Oct 18, 2020·Nature Reviews. Microbiology·Shan SuShibo Jiang
Dec 24, 2020·Nature Reviews. Immunology·Andrew J Pollard, Else M Bijker
Feb 13, 2021·NPJ Vaccines·Joshua T MonradNeil G Cherian
Aug 28, 2020·Vaccines·Mohammed A Rohaim, Muhammad Munir
Sep 4, 2020·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Pratip K ChattopadhyayUNKNOWN other members of the ISAC COVID-19 Work Group
Sep 24, 2020·Nature·Florian Krammer
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Feb 13, 2021·Vaccines·Cailin E DealObadiah J Plante
Feb 18, 2021·Reviews in Medical Virology·Arash ArashkiaUNKNOWN SARS CoV-2 Rapid Response Team of Pasteur Institute of Iran (PII)
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Datasets Mentioned


Methods Mentioned

enzyme-linked immunosorbent assay
fluorescence-activated cell sorting
density gradient centrifugation

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