SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

BioRxiv : the Preprint Server for Biology
Kizzmekia S CorbettBarney S Graham

Abstract

A SARS-CoV-2 vaccine is needed to control the global COVID-19 public health crisis. Atomic-level structures directed the application of prefusion-stabilizing mutations that improved expression and immunogenicity of betacoronavirus spike proteins. Using this established immunogen design, the release of SARS-CoV-2 sequences triggered immediate rapid manufacturing of an mRNA vaccine expressing the prefusion-stabilized SARS-CoV-2 spike trimer (mRNA-1273). Here, we show that mRNA-1273 induces both potent neutralizing antibody and CD8 T cell responses and protects against SARS-CoV-2 infection in lungs and noses of mice without evidence of immunopathology. mRNA-1273 is currently in a Phase 2 clinical trial with a trajectory towards Phase 3 efficacy evaluation.

Citations

Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Jun 24, 2020·Nature Reviews. Immunology·Nicolas Vabret
Sep 10, 2020·International Journal of Molecular Sciences·Neelu BatraAi-Ming Yu
Jul 15, 2020·Nature Nanotechnology·Helena F FlorindoRonit Satchi-Fainaro
Aug 28, 2020·Vaccines·Mohammed A Rohaim, Muhammad Munir
Jan 23, 2021·Vaccines·Michael D BuschmannDrew Weissman
Nov 13, 2020·Frontiers in Pharmacology·Junqing HuangJia-Xu Chen
Feb 3, 2021·Vaccines·Anna K BlakneyAndrew J Geall
Nov 8, 2020·Pathogens·Akshay KanakanRajesh Pandey
Dec 3, 2020·Canadian Journal of Microbiology·Raquel L RussellBrian L Mark
Dec 29, 2020·Human Vaccines & Immunotherapeutics·Ma Sophia Graciela L ReyesBeverly Lorraine Ho
Aug 14, 2020·Bioconjugate Chemistry·Valentina FranciaDominik Witzigmann
Mar 30, 2021·Frontiers in Chemistry·Ina F de la FuenteJessica L Rouge
Apr 20, 2021·Frontiers in Molecular Biosciences·Pobitra BorahDa'san M M Jaradat
May 7, 2021·Experimental & Molecular Medicine·Walter N HarringtonRichard J Webby
May 17, 2021·International Journal of Pharmaceutics·Vivek VermaLuis Padrela
Jun 17, 2021·Acta Biomaterialia·Minsong GaoJianzhao Liu

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Methods Mentioned

BETA
dissect
transgenic
ELISA

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