SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with nonsevere disease.

Thomas J GniadekTyler D Bold


The transfer of passive immunity with convalescent plasma is a promising strategy for treatment and prevention of COVID-19, but donors with a history of nonsevere disease are serologically heterogenous. The relationship between SARS-Cov-2 antigen-binding activity and neutralization activity in this population of donors has not been defined. Convalescent plasma units from 47 individuals with a history of nonsevere COVID-19 were assessed for antigen-binding activity of using three clinical diagnostic serology assays (Beckman, DiaSorin, and Roche) with different SARS-CoV-2 targets. These results were compared with functional neutralization activity using a fluorescent reporter strain of SARS-CoV-2 in a microwell assay. Positive correlations of varying strength (Spearman r = 0.37-0.52) between antigen binding and viral neutralization were identified. Donors age 48 to 75 years had the highest neutralization activity. Units in the highest tertile of binding activity for each assay were enriched (75%-82%) for those with the highest levels of neutralization. The strength of the relationship between antigen-binding activity and neutralization varies depending on the clinical assay used. Units in the highest tertile of binding activity f...Continue Reading


Apr 3, 2020·Nature·Roman WölfelClemens Wendtner
Apr 8, 2020·The Journal of Clinical Investigation·Evan M BlochAaron Ar Tobian
Apr 9, 2020·Emerging Infectious Diseases·Nisreen M A OkbaBart L Haagmans
Apr 15, 2020·Cell Host & Microbe·Xuping XiePei-Yong Shi
Apr 18, 2020·Current Protocols in Microbiology·Daniel StadlbauerFlorian Krammer
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May 18, 2020·Science·Florian Krammer, Viviana Simon
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Jul 3, 2020·MMWR. Morbidity and Mortality Weekly Report·Mark W TenfordeUNKNOWN CDC COVID-19 Response Team
Aug 15, 2020·Nature Communications·Antonio E MuruatoPei-Yong Shi

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