Apr 3, 2020

SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation

BioRxiv : the Preprint Server for Biology
Q. ZhangMeilin Jin

Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, and rapidly spread worldwide. Previous studies suggested cat could be a potential susceptible animal of SARS-CoV-2. Here, we investigated the infection of SARS-CoV-2 in cats by detecting specific serum antibodies. A cohort of serum samples were collected from cats in Wuhan, including 102 sampled after COVID-19 outbreak, and 39 prior to the outbreak. 15 of 102 (14.7%) cat sera collected after the outbreak were positive for the receptor binding domain (RBD) of SARS-CoV-2 by indirect enzyme linked immunosorbent assay (ELISA). Among the positive samples, 11 had SARS-CoV-2 neutralizing antibodies with a titer ranging from 1/20 to 1/1080. No serological cross-reactivity was detected between the SARS-CoV-2 and type I or II feline infectious peritonitis virus (FIPV). Our data demonstrates that SARS-CoV-2 has infected cat population in Wuhan during the outbreak.

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Mentioned in this Paper

Feline infectious peritonitis virus
Detected (Finding)
Coronaviridae
Enzyme-Linked Immunosorbent Assay
Receptor Binding
Felis catus
Cohort
Feline Infectious Peritonitis
Acute Respiratory Disease
Antibodies, Neutralizing

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