SARS-CoV-2 re-infection: development of an epidemiological definition from India.

Epidemiology and Infection
Aparna MukherjeeSamiran Panda

Abstract

The current investigation was conducted with the objective to develop an epidemiological case definition of possible severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) re-infection and assess its magnitude in India. The epidemiological case definition for SARS-CoV-2 re-infection was developed from literature review of data on viral kinetics. For achieving second objective, the individuals who satisfied the developed case definition for SARS-CoV-2 re-infection were contacted telephonically. Taking available evidence into consideration, re-infection with SARS-CoV-2 in our study was defined as any individual who tested positive for SARS-CoV-2 on two separate occasions by either molecular tests or rapid antigen test at an interval of at least 102 days with one negative molecular test in between. In this archive based, telephonic survey, 58 out of 1300 individuals (4.5%) fulfilled the above-mentioned definition; 38 individuals could be contacted with healthcare workers (HCWs) accounting for 31.6% of the cases. A large proportion of participants was asymptomatic and had higher Ct value during the first episode. While SARS-CoV-2 re-infection is still a rare phenomenon, there is a need for epidemiological definition of re-inf...Continue Reading

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May 2, 2021·BMJ : British Medical Journal·Kamala Thiagarajan
May 15, 2021·Diabetes & Metabolic Syndrome·Vijay Kumar JainRaju Vaishya
May 29, 2021·Nature Medicine·Jasdeep SinghSeyed E Hasnain
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