SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?

Advanced Drug Delivery Reviews
Saborni ChakrabortyTaia T Wang

Abstract

The ongoing SARS-CoV-2 pandemic has led to the focused application of resources and scientific expertise toward the goal of developing investigational vaccines to prevent COVID-19. The highly collaborative global efforts by private industry, governments and non-governmental organizations have resulted in a number of SARS-CoV-2 vaccine candidates moving to Phase III trials in a period of only months since the start of the pandemic. In this review, we provide an overview of the preclinical and clinical data on SARS-CoV-2 vaccines that are currently in Phase III clinical trials and in few cases authorized for emergency use. We further discuss relevant vaccine platforms and provide a discussion of SARS-CoV-2 antigens that may be targeted to increase the breadth and durability of vaccine responses.

References

May 6, 2003·Science·Marco A MarraRachel L Roper
May 19, 2004·Biochemical and Biophysical Research Communications·Yu HoYu-Chan Chao
Jun 25, 2004·The Journal of Infectious Diseases·Danny Tze Ming LeungPak Leong Lim
Jul 6, 2004·Journal of the American College of Cardiology·Robert E EckartUNKNOWN Department of Defense Smallpox Vaccination Clinical Evaluation Team
Dec 21, 2004·Expert Review of Vaccines·Robert BelshePaul M Mendelman
Mar 15, 2005·Virus Research·Xiaoling YuanYuwen Cong
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wai S ChanAnthony W I Lo
Jun 17, 2005·The Journal of General Virology·Patrick T W LawStephen K W Tsui
Oct 18, 2005·Journal of Biomedical Science·Chung-ke ChangTai-huang Huang
Dec 3, 2005·Biotechnology Progress·Jason HodoniczkyDavid C James
Apr 25, 2006·Biochemical and Biophysical Research Communications·Yeou-Ping TsaoShow-Li Chen
Jul 25, 2006·Nature Medicine·Amin MoghaddamPeter J M Openshaw
Aug 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wei LuBing Sun
Oct 14, 2006·Advances in Experimental Medicine and Biology·Matthew B FriemanRalph S Baric
Nov 30, 2007·Virus Research·Krishna NarayananShinji Makino
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fumihiko YasuiMichinori Kohara
Feb 24, 2009·Nature Structural & Molecular Biology·Jianhua SuiWayne A Marasco
Mar 3, 2009·Science·Damian C EkiertIan A Wilson

❮ Previous
Next ❯

Citations

Apr 4, 2021·Microorganisms·Ke-Yan LooLearn-Han Lee
May 1, 2021·Pharmaceuticals·Zhi-Peng YanChing-Lung Lai
May 8, 2021·Applied Microbiology and Biotechnology·Jungsoon LeeMaria Elena Bottazzi
Jul 22, 2021·Biochemistry. Biokhimii︠a︡·Larisa V Kordyukova, Andrey V Shanko
Aug 20, 2021·Scientific Reports·Driss Lahlou KitaneJamal Fekkak
Oct 22, 2021·Biochemical Pharmacology·Walter H MoosKonstantina Sampani

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA
bronchoalveolar
flow cytometry
electron microscopy

Clinical Trials Mentioned

NCT04497298
NCT04569786
NCT04612972
NCT04456595
NCT04508075
NCT04582344
NCT04526990
NCT04505722
NCT04536051
NCT04516746

Software Mentioned

Moderna

Related Concepts

Related Feeds

BioHub - Researcher Network

The Chan-Zuckerberg Biohub aims to support the fundamental research and develop the technologies that will enable physicians to cure, prevent, or manage all diseases in our childrens' lifetimes. The CZ Biohub brings together researchers from UC Berkeley, Stanford, and UCSF. Find the latest research from the CZ Biohub researcher network here.