SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?

Advanced Drug Delivery Reviews
Saborni ChakrabortyTaia T Wang


The ongoing SARS-CoV-2 pandemic has led to the focused application of resources and scientific expertise toward the goal of developing investigational vaccines to prevent COVID-19. The highly collaborative global efforts by private industry, governments and non-governmental organizations have resulted in a number of SARS-CoV-2 vaccine candidates moving to Phase III trials in a period of only months since the start of the pandemic. In this review, we provide an overview of the preclinical and clinical data on SARS-CoV-2 vaccines that are currently in Phase III clinical trials and in few cases authorized for emergency use. We further discuss relevant vaccine platforms and provide a discussion of SARS-CoV-2 antigens that may be targeted to increase the breadth and durability of vaccine responses.


May 6, 2003·Science·Marco A MarraRachel L Roper
May 19, 2004·Biochemical and Biophysical Research Communications·Yu HoYu-Chan Chao
Jun 25, 2004·The Journal of Infectious Diseases·Danny Tze Ming LeungPak Leong Lim
Jul 6, 2004·Journal of the American College of Cardiology·Robert E EckartUNKNOWN Department of Defense Smallpox Vaccination Clinical Evaluation Team
Dec 21, 2004·Expert Review of Vaccines·Robert BelshePaul M Mendelman
Mar 15, 2005·Virus Research·Xiaoling YuanYuwen Cong
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wai S ChanAnthony W I Lo
Jun 17, 2005·The Journal of General Virology·Patrick T W LawStephen K W Tsui
Oct 18, 2005·Journal of Biomedical Science·Chung-ke ChangTai-huang Huang
Dec 3, 2005·Biotechnology Progress·Jason HodoniczkyDavid C James
Apr 25, 2006·Biochemical and Biophysical Research Communications·Yeou-Ping TsaoShow-Li Chen
Jul 25, 2006·Nature Medicine·Amin MoghaddamPeter J M Openshaw
Aug 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wei LuBing Sun
Oct 14, 2006·Advances in Experimental Medicine and Biology·Matthew B FriemanRalph S Baric
Nov 30, 2007·Virus Research·Krishna NarayananShinji Makino
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fumihiko YasuiMichinori Kohara
Feb 24, 2009·Nature Structural & Molecular Biology·Jianhua SuiWayne A Marasco
Mar 3, 2009·Science·Damian C EkiertIan A Wilson

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