SARS-CoV-2 vaccines in development.

Nature
Florian Krammer

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in late 2019 in China and is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic. To mitigate the effects of the virus on public health, the economy and society, a vaccine is urgently needed. Here I review the development of vaccines against SARS-CoV-2. Development was initiated when the genetic sequence of the virus became available in early January 2020, and has moved at an unprecedented speed: a phase I trial started in March 2020 and there are currently more than 180 vaccines at various stages of development. Data from phase I and phase II trials are already available for several vaccine candidates, and many have moved into phase III trials. The data available so far suggest that effective and safe vaccines might become available within months, rather than years.

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Methods Mentioned

BETA
PCR
bronchoalveolar lavage
enzyme-linked immunosorbent assays
ELISA

Clinical Trials Mentioned

ISRCTN89951424
NCT04283461
NCT04352608
NCT04341389
NCT04324606
NCT04368728
NCT04368988
NCT04456595
NCT04526990
NCT04540419

Software Mentioned

CanSino
Novavax
Sinovac

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