SARS-CoV-2: vaccines in the pandemic era

Military Medical Research
Dan-Dan Li, Qi-Han Li

Abstract

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused millions of infections and deaths worldwide since its emergence in December 2019. As there is little or no natural immunity in the human population or specific anti-COVID-19 drugs, researchers from the government, academia and industry are developing vaccines at an unprecedented speed to halt the pandemic. In this review, the results of animal experiments and clinical trials on several vaccine technical platforms are summarized, and several challenges are also discussed to further promote the development, evaluation and application of vaccines during the challenging situation of the global pandemic.

References

Feb 13, 2001·Virology·T M Gallagher, M J Buchmeier
Jan 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhi-yong YangGary J Nabel
Dec 7, 2010·Journal of Structural Biology·Benjamin W NeumanMichael J Buchmeier
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Jun 30, 2016·Nature·Rafael A LaroccaDan H Barouch
Oct 7, 2016·Science·Kimberly A DowdBarney S Graham
Dec 13, 2016·Expert Opinion on Therapeutic Targets·Lanying DuShibo Jiang
Jan 13, 2018·Cell·Ioannis MitroulisTriantafyllos Chavakis
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Apr 18, 2020·Emerging Microbes & Infections·Siu-Ying LauHonglin Chen
May 4, 2020·Lancet·Nigel CurtisMihai G Netea
May 16, 2020·Cell·Blake OberfeldShiv Pillai
May 21, 2020·Nature Communications·Trevor R F SmithKate E Broderick
May 29, 2020·British Journal of Pharmacology·Simon J ClearyClive P Page
Jun 12, 2020·The Journal of Clinical Investigation·Michael J JoynerArturo Casadevall
Jun 27, 2020·BioRxiv : the Preprint Server for Biology·Lizhou ZhangHyeryun Choe
Jul 7, 2020·JAMA : the Journal of the American Medical Association·Kevin P O'CallaghanPaul A Offit
Jul 15, 2020·The New England Journal of Medicine·Lisa A JacksonUNKNOWN mRNA-1273 Study Group
Jul 30, 2020·The New England Journal of Medicine·Kizzmekia S CorbettBarney S Graham
Jul 31, 2020·Nature·Noe B MercadoDan H Barouch
Jul 31, 2020·Nature·Neeltje van DoremalenVincent J Munster
Aug 5, 2020·The Journal of Experimental Medicine·Benjamin IsraelowAkiko Iwasaki
Aug 7, 2020·Nature·Kizzmekia S CorbettBarney S Graham
Aug 14, 2020·JAMA : the Journal of the American Medical Association·Shengli XiaXiaoming Yang

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Methods Mentioned

BETA
transgenic
scanning electron microscopy

Clinical Trials Mentioned

ISRCTN89951424
NCT04368728
NCT04470427
NCT04526990
NCT04540419
NCT04505722
NCT04516746
NCT04540393
NCT04530396
NCT04564716

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