SARS-CoV-2 Vaccines: Status Report

Immunity
Fatima Amanat, Florian Krammer

Abstract

SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are being rapidly developed but will likely come too late to affect the first wave of a potential pandemic. Nevertheless, critical lessons can be learned for the development of vaccines against rapidly emerging viruses. Importantly, SARS-CoV-2 vaccines will be essential to reducing morbidity and mortality if the virus establishes itself in the population.

References

Oct 1, 1990·Epidemiology and Infection·K A CallowD A Tyrrell
Feb 9, 2008·Emerging Infectious Diseases·Li-Ping WuGuo-Dong Liang
Jun 23, 2009·Expert Review of Vaccines·Rachel L Roper, Kristina E Rehm
Feb 2, 2011·PloS One·Elodie TeissierEve-Isabelle Pécheur
Apr 20, 2011·Annals of Medicine·Mark W Hull, Julio S G Montaner
Nov 23, 2013·Infection & chemotherapy·Theodore F Tsai
Feb 28, 2015·Methods in Molecular Biology·Anthony R Fehr, Stanley Perlman
Feb 28, 2015·Nature Reviews. Drug Discovery·Florian Krammer, Peter Palese
Feb 19, 2016·Science Translational Medicine·Thomas LukeMatthew B Frieman
Dec 23, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rameshwar U Kadam, Ian A Wilson
Jun 7, 2017·Emerging Infectious Diseases·Pyoeng Gyun ChoeMyoung-Don Oh
Jul 1, 2017·Science Translational Medicine·Timothy P SheahanRalph S Baric
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jesper PallesenJason S McLellan
Mar 6, 2018·The Journal of Infectious Diseases·Emily J ErbeldingAnthony S Fauci
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Aug 21, 2019·Frontiers in Microbiology·Chean Yeah YongWen Siang Tan
Nov 28, 2019·The New England Journal of Medicine·Sabue MulanguUNKNOWN PALM Consortium Study Team
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 1, 2020·The New England Journal of Medicine·Michelle L HolshueUNKNOWN Washington State 2019-nCoV Case Investigation Team
Feb 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Emmie de WitHeinz Feldmann
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Feb 28, 2020·JAMA : the Journal of the American Medical Association·Lan LanHaibo Xu
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19

❮ Previous
Next ❯

Citations

Apr 23, 2020·Journal of Cellular and Molecular Medicine·Hua LiJunbo Ge
May 30, 2020·Vector Borne and Zoonotic Diseases·Willy A Valdivia-Granda, Jürgen A Richt
May 30, 2020·International Journal of Environmental Research and Public Health·Fei ZhaiJiankun Liang
May 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tulika SinghSallie R Permar
May 24, 2020·The FEBS Journal·Cassandra L AtzrodtThomas P Clements
Jun 17, 2020·Expert Opinion on Drug Discovery·Mohamed BoudjelalImadul Islam
Jun 4, 2020·Pathogens·Sabari Nath Neerukonda, Upendra Katneni
Jun 20, 2020·Journal of Cellular Physiology·Mahnaz GhaebiMajid Ahmadi
Apr 23, 2020·Journal of Medical Virology·Ji-Wang Chen, Ji-Ming Chen
Jun 9, 2020·The Journal of Clinical Investigation·Leonard AngkaRebecca C Auer
Jun 24, 2020·Expert Review of Anti-infective Therapy·Gabriela PalestinoSergio Rosales-Mendoza
Jun 26, 2020·Current Protocols in Microbiology·Fatima AmanatFlorian Krammer
Jun 22, 2020·Journal of Crohn's & Colitis·P C GrunertA Stallmach
Jul 8, 2020·Pathogens·Ahmed S Abdel-Moneim, Elsayed M Abdelwhab
Jun 17, 2020·Critical Care Medicine·Lewis J KaplanUNKNOWN Editors of Critical Care Medicine:
Jun 10, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ashley L St John, Abhay P S Rathore
May 3, 2020·British Journal of Pharmacology·Steve P H AlexanderMichael Spedding
Jul 31, 2020·Laboratory Medicine·Kamal Kant SahuJan Cerny
Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Aug 23, 2020·Pediatric Radiology·Victor J SeghersThierry A G M Huisman
Aug 26, 2020·Pathogens and Disease·Jitendra Singh Rathore, Chaitali Ghosh
Sep 5, 2020·Seminars in Liver Disease·Maria J Lizardo-ThiebaudNalu Navarro-Alvarez
May 20, 2020·The Journal of Applied Laboratory Medicine·Raymond T SuhandynataRobert L Fitzgerald
Sep 15, 2020·Cardiovascular Drugs and Therapy·R S SoumyaK G Raghu
Jul 30, 2020·The Journal of Pharmacology and Experimental Therapeutics·Zeenat A ShyrWei Zheng
Sep 17, 2020·Human Vaccines & Immunotherapeutics·Idris Nasir AbdullahiAbdurrahman El-Fulaty Ahmad
Sep 9, 2020·Emerging Microbes & Infections·Tingting LiNingshao Xia
Aug 18, 2020·Transboundary and Emerging Diseases·Guangzhi ZhangShangjin Cui
Sep 8, 2020·Environmental Microbiology·Harald Brüssow
Sep 30, 2020·Physiological Genomics·Casey A PollardAndrea L Nestor-Kalinoski
Jun 21, 2020·Journal of Clinical Medicine·David WuDeepak Shukla
Sep 19, 2020·Infection and Drug Resistance·Zahra YazdaniReza Valadan

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT04257656
NCT04252664
NCT04280705
NCT04255017
NCT04276688
NCT04264858
NCT04287686
NCT02788188
NCT04283461

Software Mentioned

Curevac

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Veterinary Record
Shao-Lun ZhaiDan Wang
American Journal of Clinical Pathology
Ahmed BabikerJeannette Guarner
The New England Journal of Medicine
Xiaoxia LuChinese Pediatric Novel Coronavirus Study Team
© 2021 Meta ULC. All rights reserved