SARS-CoV-2 variants: A double-edged sword?

Experimental Biology and Medicine
Manasi P JogalekarPrakash Gangadaran


Since the worldwide emergence of the COVID-19 outbreak, there have been international concerns about the possible viral evolution into variants with underlying mutations that may contribute to their increased transmissibility, disease severity, risk of death, and their potential escape from the immune response or may even lead to its extinction. Rigorous surveillance has revealed the variants harboring mutations in the spike protein, the main target of neutralizing antibodies generated through vaccination or herd immunity. In this review, we have highlighted major SARS-CoV-2 variants as well as other local strains along with their specific mutations, suspected changes in their characteristics, and their impact on the current pandemic and vaccine efficacy. We have also emphasized the need to develop widely protective interventions to curb further transmission of variants.


Feb 20, 2020·Nature Microbiology·Nathan D GrubaughEdward C Holmes
Nov 12, 2020·Science·Bas B Oude MunninkMarion P G Koopmans
Nov 20, 2020·Experimental Biology and Medicine·Madhumitha ManivannanPrakash Gangadaran
Jan 7, 2021·JAMA : the Journal of the American Medical Association·Adam S Lauring, Emma B Hodcroft
Jan 16, 2021·The Lancet Infectious Diseases·Simona FiorentiniArnaldo Caruso
Jan 22, 2021·MMWR. Morbidity and Mortality Weekly Report·Summer E GallowayVivien G Dugan
Feb 8, 2021·Lancet·Talha Burki
Feb 15, 2021·Lancet·Arnaud FontanetDevi Sridhar
Mar 9, 2021·Nature·Pengfei WangDavid D Ho
Mar 18, 2021·The New England Journal of Medicine·Kai WuDarin K Edwards

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