SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy.

The Journal of Clinical Investigation
Arturo CasadevallLiise-Anne Pirofski

Abstract

Most patients with COVID-19 lack antibody to SARS-CoV-2 in the first 10 days of illness while the virus drives disease pathogenesis. SARS-CoV-2 antibody deficiency in the setting of a tissue viral burden suggests that using an antibody as a therapeutic agent would augment the antiviral immune response. In this issue of the JCI, Wang and collaborators describe the kinetics of viral load and the antibody responses of 23 individuals with COVID-19 experiencing mild and severe disease. The researchers found that (a) individuals with mild and severe disease produced neutralizing IgG to SARS-CoV-2 10 days after disease onset, (b) SARS-CoV-2 persisted longer in those with severe disease, and (c) there was cross-reactivity between antibodies to SARS-CoV-1 and SARS-CoV-2, but only antibodies from patients with COVID-19 neutralized SARS-CoV-2. These observations provide important information on the serological response to SARS-CoV-2 of hospitalized patients with COVID-19 that can inform the use of convalescent plasma therapy.

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Citations

Sep 17, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Eleni KaratzaVangelis Karalis
Sep 10, 2020·International Journal of Molecular Sciences·Neelu BatraAi-Ming Yu
Aug 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arturo CasadevallLiise-Anne Pirofski
Dec 5, 2020·Nature·Katherine McMahanDan H Barouch
Apr 8, 2021·JMIR Public Health and Surveillance·Henry T PengAndrew Beckett
Dec 29, 2020·Med·Arturo CasadevallNigel Paneth
May 10, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·S MahapatraC B K Mohanty
Jun 30, 2021·Angiogenesis·David M SmadjaArjan W Griffioen

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