SARS-CoV2 and pregnancy: An invisible enemy?

American Journal of Reproductive Immunology : AJRI
Sonam VermaIndira U Mysorekar

Abstract

Coronavirus disease 2019 or COVID-19 is an emerging viral disease caused by a member of the betacoronavirus family, SARS-CoV-2. Since its' emergence in December 2019, it has rapidly caused close to half a million fatalities globally. Data regarding the impact of COVID-19 on pregnancy are limited. Here, we review pathological findings in placentas from women who tested positive for SARS-CoV-2 as well as information on pregnancy outcomes associated with related and highly pathogenic coronaviruses (ie, severe acute respiratory syndrome (SARS-COV) and the Middle East respiratory syndrome, MERS). We present immune-inflammatory correlates of COVID-19 in pregnancy and review the role of the Renin Angiotensin System in the pathogenesis of COVID-19 in pregnancy. Greater understanding of the pathogenesis of SARS-CoV-2 in the placenta will yield important insight into potential therapeutic interventions for pregnant women with COVID-19.

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Citations

Oct 13, 2020·Fetal and Pediatric Pathology·Mai HeLouis P Dehner
Oct 30, 2020·Frontiers in Immunology·Elaine L ParkerIndira U Mysorekar
Feb 10, 2021·Journal of Medical Virology·C Merve Seymen
Oct 2, 2020·American Journal of Reproductive Immunology : AJRI·Surendra SharmaAihua Liao
Apr 28, 2021·BMC Pregnancy and Childbirth·Itzíar CarrascoMaría Luisa Navarro
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Oct 16, 2021·BJOG : an International Journal of Obstetrics and Gynaecology·E JoubertC N Amin

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Methods Mentioned

BETA
cesarean section

Software Mentioned

MedArkiv
BioArkiv

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