SARS-CoV2 spike protein gene variants with N501T and G142D mutation-dominated infections in mink in the United States.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Hugh Y Cai, Allison Cai

Abstract

Large numbers of mink have been infected with SARS-CoV2 containing the spike protein Y453F mutation in Europe, causing zoonosis concerns. To evaluate the genetic characteristics of the U.S. and Canadian mink-derived SARS-CoV2 sequences, we analyzed all animal-derived (977) and all Canadian (19,529) and U.S. (173,277) SARS-CoV2 sequences deposited in GISAID from December 2019 to March 12, 2021, and identified 2 dominant novel variants, the N501T-G142D variant and N501T-G142D-F486L variant, in the U.S. mink-derived SARS-CoV2 sequences. These variants were not found in mink from Canada or other countries. The Y453F mutation was not identified in the mink-derived sequences in the United States and Canada. The N501T mutation occurred 2 mo earlier in humans than in mink in the United States, and the novel N501T-G142D and N501T-G142D-F486L variants were found in humans prior to mink. Our results suggest that the novel SARS-CoV2 variants may have evolved during human infection and were then transmitted to mink populations in the United States.

References

Feb 25, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tung Phan
Jun 20, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Nadia OreshkovaArjan Stegeman
Sep 15, 2020·The Veterinary Quarterly·Takuma HayashiIkuo Konishi
Nov 12, 2020·Science·Bas B Oude MunninkMarion P G Koopmans
Jan 2, 2021·PeerJ·Ahmed ElaswadAwad A Shehata
Jan 23, 2021·Science·Kai Kupferschmidt
Feb 6, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Helle Daugaard LarsenKåre Mølbak
Mar 3, 2021·Journal of Virology·Carolina M VolochAna Tereza R de Vasconcelos
Mar 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yinghui LiuQiang Ding

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Citations

Nov 4, 2021·Cellular and Molecular Life Sciences : CMLS·Deepali GuptaPunit Kaur

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Methods Mentioned

BETA
GISAID

Software Mentioned

GISAID
Geneious
BLAST

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