SARS in the Intensive Care Unit

Current Infectious Disease Reports
Gavin M Joynt, H. Y. Yap

Abstract

Approximately 20% of patients with severe acute respiratory syndrome (SARS) develop respiratory failure that requires admission to an intensive care unit (ICU). Old age, comorbidity, and elevated lactate dehydrogenase on hospital admission are associated with increased risk for ICU admission. ICU admission usually is late and occurs 8 to 10 days after symptom onset. Acute respiratory distress syndrome occurs in almost all admitted patients and most require mechanical ventilation. ICU admission is associated with significant morbidity, particularly an apparent increase in the incidence of barotrauma and nosocomial sepsis. Long-term mortality for patients admitted to the ICU ranges from 30% to 50%. Many procedures in ICUs pose a high risk for transmission of SARS coronavirus to health care workers. Contact and airborne infection isolation precautions, in addition to standard precautions, should be applied when caring for patients with SARS. Ensuring staff safety is important to maintain staff morale and delivery of adequate services.

References

May 1, 1992·The American Review of Respiratory Disease·J P MitchellD P Schuster
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jan 1, 1996·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J S Garner
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·L GattinoniA Lissoni
Jul 21, 1998·JAMA : the Journal of the American Medical Association·G U MeduriE A Tolley
Jul 21, 1998·JAMA : the Journal of the American Medical Association·C Brun-Buisson, L Brochard
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jul 6, 2000·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·D Pittet
Sep 1, 2001·The New England Journal of Medicine·L GattinoniUNKNOWN Prone-Supine Study Group
Sep 3, 2002·Current Opinion in Critical Care·Luciano GattinoniRiccarda Russo
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Peter Q EichackerCharles Natanson
Feb 21, 2003·The New England Journal of Medicine·Margaret S HerridgeUNKNOWN Canadian Critical Care Trials Group
Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Apr 12, 2003·Critical Care Medicine·B Taylor Thompson
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 25, 2003·Lancet·Thomas Sing Tao LiGavin M Joynt
May 8, 2003·JAMA : the Journal of the American Medical Association·Christopher M BoothAllan S Detsky
May 10, 2003·Lancet·Brian Tomlinson, Clive Cockram
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Jul 17, 2003·JAMA : the Journal of the American Medical Association·Robert A FowlerUNKNOWN Toronto SARS Critical Care Group
Jul 17, 2003·JAMA : the Journal of the American Medical Association·Thomas W K LewSoon-Keng Goh
Aug 30, 2003·American Journal of Respiratory and Critical Care Medicine·James C HoKenneth W Tsang
Oct 2, 2003·Emerging Infectious Diseases·Ping Tim TsuiSik To Lai
Oct 29, 2003·Clinical Radiology·G E AntonioA T Ahuja
Nov 5, 2003·Annals of Internal Medicine·Kin Wing ChoiUNKNOWN Princess Margaret Hospital SARS Study Group
Dec 19, 2003·The New England Journal of Medicine·Joseph S M PeirisKlaus Stöhr
Jan 24, 2004·Intensive Care Medicine·Charles D GomersallPatricia Leung
Apr 7, 2004·The Journal of Infection·Ai Ping Chua, Kang Hoe Lee

❮ Previous
Next ❯

Citations

Mar 23, 2010·Intensive Care Medicine·Bruce L TaylorUNKNOWN European Society of Intensive Care Medicine's Task Force for intensive care unit triage during an influenza epidemic or mass
Jun 24, 2006·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Lewis RubinsonDaniel Talmor
Jan 12, 2011·Journal of Intensive Care Medicine·Mary-Elise ManuellRichard T Ellison
Jan 28, 2021·International Journal of Environmental Research and Public Health·Leonardo B FurstenauNicola Luigi Bragazzi
Mar 6, 2021·International Journal of Biological Macromolecules·Pedro F N SouzaRaquel C Montenegro
Mar 12, 2021·Annals of Medicine and Surgery·Semagn Mekonnen AbateBahiru Mantefardo
Jul 1, 2021·British Journal of Hospital Medicine·M GabrielliUNKNOWN Gemelli Against COVID 2019

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.