SARS-like WIV1-CoV poised for human emergence

Proceedings of the National Academy of Sciences of the United States of America
Vineet D MenacheryRalph S Baric

Abstract

Outbreaks from zoonotic sources represent a threat to both human disease as well as the global economy. Despite a wealth of metagenomics studies, methods to leverage these datasets to identify future threats are underdeveloped. In this study, we describe an approach that combines existing metagenomics data with reverse genetics to engineer reagents to evaluate emergence and pathogenic potential of circulating zoonotic viruses. Focusing on the severe acute respiratory syndrome (SARS)-like viruses, the results indicate that the WIV1-coronavirus (CoV) cluster has the ability to directly infect and may undergo limited transmission in human populations. However, in vivo attenuation suggests additional adaptation is required for epidemic disease. Importantly, available SARS monoclonal antibodies offered success in limiting viral infection absent from available vaccine approaches. Together, the data highlight the utility of a platform to identify and prioritize prepandemic strains harbored in animal reservoirs and document the threat posed by WIV1-CoV for emergence in human populations.

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Citations

Mar 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Vincent Racaniello
Apr 21, 2016·Trends in Microbiology·Susanna K P Lau, Patrick C Y Woo
May 24, 2016·Virus Research·Samaporn TeeravechyanAnan Jongkaewwattana
Oct 25, 2016·Trends in Microbiology·Diego ForniManuela Sironi
Feb 20, 2017·Current Opinion in Virology·Vineet D MenacheryRalph S Baric
Feb 18, 2017·Pathogens·Alexandra Schäfer, Ralph S Baric
Mar 4, 2018·Virologica Sinica·Ning WangZheng-Li Shi
Jul 7, 2018·Journal of Virology·Vineet D MenacheryRalph S Baric
Sep 11, 2018·Acta Crystallographica. Section D, Structural Biology·Lei YanBei Yang
Aug 24, 2017·MBio·Vineet D MenacheryRalph S Baric
Sep 14, 2018·Emerging Microbes & Infections·Dan HuChangjun Wang
Mar 9, 2019·Expert Opinion on Drug Discovery·Allison L Totura, Sina Bavari
Apr 20, 2019·PLoS Biology·Cody J Warren, Sara L Sawyer
Jun 28, 2016·Nature Reviews. Microbiology·Emmie de WitVincent J Munster
Dec 4, 2019·Nature Structural & Molecular Biology·Young-Jun ParkDavid Veesler
Jul 1, 2017·Science Translational Medicine·Timothy P SheahanRalph S Baric
Dec 6, 2019·Journal of Virology·Vineet D MenacheryRalph S Baric
Jun 3, 2020·International Journal of Molecular Sciences·Xinling WangShibo Jiang
Jul 8, 2020·Pathogens·Ahmed S Abdel-Moneim, Elsayed M Abdelwhab
May 15, 2020·Nature·Sin Fun SiaHui-Ling Yen
Jul 31, 2020·Emerging Infectious Diseases·Susanna K P LauPatrick C Y Woo
Jul 24, 2020·The American Journal of Tropical Medicine and Hygiene·David M MorensJeffery K Taubenberger
Jul 30, 2020·The American Journal of Tropical Medicine and Hygiene·Gregory Brett MoreauBarbara J Mann
Sep 12, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Rafal Butowt, Christopher S von Bartheld
Sep 17, 2020·Vector Borne and Zoonotic Diseases·Jian-Yong WuXue-Yun Yang
Mar 30, 2017·Emerging Microbes & Infections·Lihua WangGuodong Liang

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