Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice.

Acta Pharmacologica Sinica
Yan-Yan YuJing-Ya Li

Abstract

Insulin resistance is a major cause of type 2 diabetes and metabolic syndrome. Macrophage infiltration into obese adipose tissue promotes inflammatory responses that contribute to the pathogenesis of insulin resistance. Suppression of adipose tissue inflammatory responses is postulated to increase insulin sensitivity in obese patients and animals. Sarsasapogenin (ZGY) is one of the metabolites of timosaponin AIII in the gut, which has been shown to exert anti-inflammatory action. In this study, we investigated the effects of ZGY treatment on obesity-induced insulin resistance in mice. We showed that pretreatment with ZGY (80 mg·kg-1·d-1, ig, for 18 days) significantly inhibited acute adipose tissue inflammatory responses in LPS-treated mice. In high-fat diet (HFD)-fed obese mice, oral administration of ZGY (80 mg·kg-1·d-1, for 6 weeks) ameliorated insulin resistance and alleviated inflammation in adipose tissues by reducing the infiltration of macrophages. Furthermore, we demonstrated that ZGY not only directly inhibited inflammatory responses in macrophages and adipocytes, but also interrupts the crosstalk between macrophages and adipocytes in vitro, improving adipocyte insulin resistance. The insulin-sensitizing and anti-infl...Continue Reading

References

Aug 27, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Takayoshi SuganamiYoshihiro Ogawa
Aug 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·Carey N LumengAlan R Saltiel
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Mar 30, 2007·Journal of Chromatography. a·Geoffrey C KiteMonique S J Simmonds
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
May 15, 2007·Gastroenterology·Steven E ShoelsonAfia Naaz
Dec 7, 2007·FEBS Letters·Carl de Luca, Jerrold M Olefsky
Apr 11, 2008·Nature Reviews. Molecular Cell Biology·Adilson GuilhermeMichael P Czech
Aug 21, 2008·Journal of Integrative Plant Biology·Xue-Feng HuangLing-Yi Kong
Sep 3, 2009·Molecular and Cellular Endocrinology·Sandra GalicGregory R Steinberg
Feb 13, 2010·Annual Review of Physiology·Jerrold M Olefsky, Christopher K Glass
Jan 12, 2011·Annual Review of Immunology·Margaret F Gregor, Gökhan S Hotamisligil
Jan 15, 2011·Nature Reviews. Immunology·Marc Y Donath, Steven E Shoelson
May 19, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·David L MorrisCarey N Lumeng
Jun 3, 2011·The Journal of Clinical Investigation·Carey N Lumeng, Alan R Saltiel
Nov 3, 2011·American Journal of Physiology. Endocrinology and Metabolism·Misaki IwashitaTomoichiro Asano
Mar 13, 2012·Annual Review of Nutrition·Shengyi SunLing Qi
Feb 19, 2013·Cell·Andrew M F Johnson, Jerrold M Olefsky
Nov 11, 2015·Nature Reviews. Endocrinology·Denise E Lackey, Jerrold M Olefsky
Nov 19, 2015·Frontiers in Physiology·Leandro C Freitas LimaCamille de Moura Balarini
Jan 4, 2017·The Journal of Clinical Investigation·Alan R Saltiel, Jerrold M Olefsky
Apr 10, 2018·Trends in Pharmacological Sciences·Kristin R PetersonAlyssa H Hasty
Apr 24, 2018·Phytotherapy Research : PTR·Yao-Wu LiuTao-Yun Wang
May 18, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Paulina OrmazabalRoberta Masella
Oct 20, 2018·Current Diabetes Reports·Thomas Reinehr, Christian Ludwig Roth

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