SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer

Oncogene
Constanze ZellerSiegfried Scherneck

Abstract

Loss of heterozygosity (LOH) and in silico expression analysis were applied to identify genes significantly downregulated in breast cancer within the genomic interval 6q23-25. Systematic comparison of candidate EST sequences with genomic sequences from this interval revealed the genomic structure of a potential target gene on 6q24.3, which we called SAM and SH3 domain containing 1 (SASH1). Loss of the gene-internal marker D6S311, found in 30% of primary breast cancer, was significantly correlated with poor survival and increase in tumor size. Two SASH1 transcripts of approximately 4.4 and 7.5 kb exist and are predominantly transcribed in the human breast, lung, thyroid, spleen, placenta and thymus. In breast cancer cell lines, SASH1 is only expressed at low levels. SASH1 is downregulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. In addition, SASH1 is also downregulated in tumors of the lung and thyroid. Analysis of the protein domain structure revealed that SASH1 is a member of a recently described family of SH3/SAM adapter molecules and thus suggests a role in signaling pathways. We assume that SASH1 is a new tumor suppressor gene possibly involved in tumorigenesi...Continue Reading

References

Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Dec 1, 1984·Cancer Genetics and Cytogenetics·D H Wurster-HillL H Maurer
Feb 16, 1995·Nature·T Pawson
Jan 1, 1997·Current Opinion in Oncology·G Casey
Jan 1, 1999·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·T NagaseO Ohara
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·V SrikantanS Srivastava
Dec 19, 2001·The Journal of Pathology·Almut GoezeIver Petersen
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·A Meindl, UNKNOWN German Consortium for Hereditary Breast and Ovarian Cancer
Apr 11, 2002·Virchows Archiv : an International Journal of Pathology·Ingrid StallmachMadeleine Pfaltz
Apr 16, 2002·Journal of Medical Genetics·M M de JongE G E de Vries

❮ Previous
Next ❯

Citations

May 4, 2005·Breast Cancer Research and Treatment·Hiroaki FujiiOkio Hino
Apr 11, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·En-guo ChenJi-song Zhang
Aug 24, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Liu YangJian Li
Oct 18, 2005·Molecular and Cellular Biology·Sandra BeerBernhard Holzmann
Jun 19, 2014·Oncology Reports·Thale Kristin OlsenPetter Brandal
Aug 27, 2015·European Journal of Immunology·Daniel SchällSandra Beer-Hammer
Sep 10, 2015·Journal of Shoulder and Elbow Surgery·Robert Z TashjianCraig C Teerlink
Dec 15, 2010·Kidney International·Caitrin W McDonoughDonald W Bowden
Aug 9, 2011·The International Journal of Biochemistry & Cell Biology·Melanie MartiniKlaus-Peter Janssen
Jul 24, 2015·The Journal of Investigative Dermatology·Yiqun G ShellmanTheresa R Pacheco
Sep 1, 2015·Atherosclerosis·Henri WeidmannEwa Ninio
Aug 6, 2005·Cancer Genetics and Cytogenetics·Norma J NowakAnirban Maitra
Mar 11, 2008·Cancer Genetics and Cytogenetics·Camelia-Maria MonoranuWolfgang Roggendorf
Jul 24, 2004·American Journal of Human Genetics·J E Bailey-WilsonM W Anderson
Oct 22, 2014·European Journal of Immunology·Fee SchmittSandra Beer-Hammer
Oct 2, 2015·Disease Markers·Liu YangMei Liu
Oct 26, 2005·The Breast : Official Journal of the European Society of Mastology·Marc J van de Vijver
Nov 11, 2016·Cell Death & Disease·Joshua T BurgessDerek J Richard
Nov 26, 2016·Journal of Cellular and Molecular Medicine·Ding'an ZhouQinghe Xing
Mar 29, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Margaret C ThompsonRichard J Gilbertson
Apr 7, 2017·Journal of Cellular and Molecular Medicine·Ding'an ZhouQinghe Xing
Dec 18, 2018·International Journal of Cancer. Journal International Du Cancer·Shuichi WatanabeShinji Tanaka
Jul 7, 2009·Journal of Lipid Research·Yu Zi Zheng, Leonard J Foster
Oct 2, 2012·Molecular Medicine Reports·Sheyu LinLin He

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.