SASP regulation by noncoding RNA

Mechanisms of Ageing and Development
Amaresh C PandaMyriam Gorospe

Abstract

Noncoding RNAs (ncRNAs), including micro (mi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs, control specific gene expression programs by regulating transcriptional, post-transcriptional, and post-translational processes. Through their broad influence on protein expression and function, ncRNAs have been implicated in virtually all cellular processes such as proliferation, senescence, quiescence, differentiation, apoptosis, and the stress and immune responses. Senescence is a cellular phenotype associated with the physiologic decline of aging and with age-related pathologies. Besides their characteristic terminal growth arrest and differential gene expression programs, senescent cells are known to secrete potent pro-inflammatory, angiogenic, and tissue-remodeling factors. This important trait, known as the senescence-associated secretory phenotype (SASP), influences many biological processes such as tissue repair and regeneration, tumorigenesis, and the aging-associated pro-inflammatory state. Here, we review the microRNAs, lncRNAs, and circRNAs that influence the production of SASP factors and discuss the rising interest in SASP-regulatory ncRNAs as diagnostic and therapeutic targets.

References

Feb 8, 1991·Cell·J M NigroB Vogelstein
Oct 9, 1986·Nature·A KosH Schellekens
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Jul 23, 1998·Critical Reviews in Eukaryotic Gene Expression·V J CristofaloM Tresini
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KrtolicaJ Campisi
Aug 30, 2002·The International Journal of Biochemistry & Cell Biology·Ana Krtolica, Judith Campisi
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hong ZhangStanley N Cohen
Mar 1, 1965·Experimental Cell Research·L HAYFLICK
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Dec 19, 2003·Genes & Development·Rui YiBryan R Cullen
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Nov 13, 2004·Nature·Matthew N PoyMarkus Stoffel
Dec 3, 2004·Genes & Development·Jinju HanV Narry Kim
Apr 27, 2005·Nature Reviews. Molecular Cell Biology·V Narry Kim
Nov 8, 2005·Cell·Richard I GregoryRamin Shiekhattar
Nov 26, 2005·Science·Kyle Kai-How FarhDavid P Bartel
Mar 3, 2006·Genes & Development·Marco Antonio Valencia-SanchezRoy Parker
Mar 15, 2006·Cell·Ronald H A Plasterk
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esmerina TiliCarlo Maria Croce
Dec 7, 2007·Genes & Development·Adam S AdlerHoward Y Chang
Dec 7, 2007·Cancer Research·Xingyue HeGregory J Hannon
Mar 21, 2008·Current Opinion in Cell Biology·Alexandre Prieur, Daniel S Peeper
Jun 3, 2008·Nature Cell Biology·Darren J BakerJan M van Deursen
Jan 10, 2009·Nature Reviews. Cancer·Thomas Kuilman, Daniel S Peeper
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
Sep 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gang LiuEdward Abraham
Jan 19, 2010·Annual Review of Pathology·Jean-Philippe CoppéJudith Campisi
May 7, 2010·Trends in Molecular Medicine·Adam FreundJudith Campisi
Jun 10, 2010·Journal of the American Chemical Society·Douglas D YoungAlexander Deiters
Nov 17, 2010·Genes & Development·Thomas KuilmanDaniel S Peeper
May 20, 2011·Trends in Genetics : TIG·Myriam Gorospe, Kotb Abdelmohsen
Aug 30, 2011·Nature·Mitchell GuttmanEric S Lander

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Citations

Jul 14, 2017·Aging Cell·Mathieu Deschênes, Benoit Chabot
Aug 11, 2017·International Journal of Molecular Sciences·Weili Xu, Anis Larbi
Apr 22, 2019·Biomolecules & Therapeutics·Hyun LimHyun Pyo Kim
Dec 14, 2019·Aging Cell·Luigi FerrucciRafael de Cabo
May 24, 2020·International Journal of Molecular Sciences·Petra Cazzanelli, Karin Wuertz-Kozak
Jul 4, 2018·Genes & Development·Kyoung Mi KimMyriam Gorospe
Jun 27, 2019·International Journal of Molecular Sciences·Simona GrecoFabio Martelli
Jun 30, 2019·Nucleic Acids Research·Gabriel CasellaMyriam Gorospe
Mar 14, 2019·International Journal of Molecular Sciences·Rüdiger Hardeland
May 31, 2019·Wiley Interdisciplinary Reviews. RNA·Gabriel CasellaMyriam Gorospe
Dec 17, 2020·Cells·Jagoda Adamczyk-Grochala, Anna Lewinska
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Jingyi CaiZhihe Zhao
Apr 16, 2021·Frontiers in Cell and Developmental Biology·Ruchi Kumari, Parmjit Jat
May 1, 2021·Life·Kelly E LeonRaquel Buj
May 24, 2021·Cancer Cell International·Menggang ZhangWenzhi Guo
Jul 6, 2021·Frontiers in Immunology·Ross A CampbellKatie J Mylonas
Nov 13, 2021·Cellular and Molecular Neurobiology·Lin Zhang, Jian Xia

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