SASS6 promotes proliferation of esophageal squamous carcinoma cells by inhibiting the p53 signaling pathway.

Carcinogenesis
Yuanji XuYuanmei Chen

Abstract

SASS6 encodes for the Homo sapiens SAS-6 centriolar assembly protein and is important for proper centrosome formation. Although centrosomes are amplified in a wide variety of tumor types, abnormally high SASS6 expression had previously only been identified in colon cancer. Moreover, the role of SASS6 in esophageal squamous cell carcinoma (ESCC) pathogenesis has not yet been elucidated. The aim of this study was to investigate the role and mechanisms of SASS6 in ESCC. In this study, we found that the mRNA and protein levels of SASS6 were increased in human ESCC samples. In addition, SASS6 protein expression was associated with the esophageal cancer stage and negatively affected survival of patients with ESCC. Furthermore, silencing of SASS6 inhibited cell growth and promoted apoptosis of ESCC cells in vitro and inhibited xenograft tumor formation in vivo. A genetic cluster and pathway analysis showed that SASS6 regulated the p53 signaling pathway. Western blot demonstrated that CCND2, GADD45A and EIF4EBP1 protein expression decreased and that TP53 protein expression increased after the knockdown of SASS6 in ESCC cells. Therefore, SASS6 promoted the proliferation of esophageal cancer by inhibiting the p53 signaling pathway. SASS6...Continue Reading

References

Oct 15, 1998·Nature Genetics·S Doxsey
Dec 14, 1999·The American Journal of Pathology·W L Lingle, J L Salisbury
Apr 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·B SkyldbergG Auer
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Wilma L LingleJeffrey L Salisbury
Apr 23, 2003·European Urology·K KawamuraK Suzuki
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Feng JiangRuth L Katz
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Gina D TranPhilip R Taylor
Nov 21, 2007·Biology of the Cell·Constantina ConstantinouMichael J Clemens
Oct 18, 2011·Genetics and Molecular Research : GMR·F Attaran-BandarabadiM Nassiri
Feb 22, 2012·Journal of Cell Science·Christian ArquintErich A Nigg
Mar 30, 2012·Omics : a Journal of Integrative Biology·Guangchuang YuQing-Yu He
Feb 5, 2013·Lancet·Arjun PennathurJames D Luketich
Mar 5, 2014·The Journal of Cell Biology·Debora KellerPierre Gönczy
Nov 2, 2014·International Journal of Cancer. Journal International Du Cancer·Sampath RamachandiranLeon Bernal-Mizrachi
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Aug 5, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Olca BasturkDavid S Klimstra
Dec 14, 2018·Frontiers in Oncology·Elizabeth R SmithXiang-Xi Xu
Dec 19, 2018·European Surgery : ACA : Acta Chirurgica Austriaca·Sonja Kappel-LatifUNKNOWN Pancho trialists and for the Medical University of Vienna p53research group
Feb 8, 2019·Pathology International·Toshihide KomatsubaraNoriyoshi Fukushima
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Zhuo WangChangzheng Li
Aug 23, 2019·Results and Problems in Cell Differentiation·Arunabha Bose, Sorab N Dalal
Sep 16, 2019·International Journal of Clinical Oncology·Yoshihiko MaeharaMasaki Mori

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis