SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells

Toxicology and Applied Pharmacology
Feng WuMax Costa

Abstract

The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure. In our previous study, we reported that SATB2 gene expression was induced in human bronchial epithelial BEAS-2B cells transformed by arsenic, chromium, nickel and vanadium. In this study, we show that ectopic expression of SATB2 in the normal human bronchial epithelial cell-line BEAS-2B increased anchorage-independent growth and cell migration, meanwhile, shRNA-mediated knockdown of SATB2 significantly decreased anchorage-independent growth in Ni transformed BEAS-2B cells. RNA sequencing analyses of SATB2 regulated genes revealed the enrichment of those involved in cytoskeleton, cell adhesion and cell-movement pathways. Our evidence supports the hypothesis that SATB2 plays an important role in BEAS-2B cell transformation.

References

Jan 1, 1995·Critical Reviews in Eukaryotic Gene Expression·C ChangA Mizokami
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 1, 2007·Archives of Oral Biology·Ariadne LetraJosé Mauro Granjeiro
Nov 1, 2007·Chemical Research in Toxicology·Konstantin Salnikow, Anatoly Zhitkovich
Mar 13, 2008·The European Journal of Neuroscience·Andrea B GyorgyDenes V Agoston
Jan 21, 2009·Cancer Metastasis Reviews·Alan Hall
Aug 1, 2009·Cancer Cell International·Neill PataniKefah Mokbel
Sep 3, 2009·Biochemical and Biophysical Research Communications·Inna B SabirzhanovaTimothy G Clark
Sep 4, 2009·Molecular Pharmacology·Susan OldfieldNeil V Marrion
Apr 14, 2010·Particle and Fibre Toxicology·Elizabeth A RondiniAlison K Bauer
Dec 24, 2010·Genome Biology·Alicia OshlackMatthew D Young
Aug 30, 2011·Biochimica Et Biophysica Acta·Charles K Abrams, Steven S Scherer
Dec 17, 2011·Journal of Toxicology·Victor D MartinezWan L Lam
May 9, 2012·Experimental Lung Research·Christine TyrrellMary C McElroy
Sep 19, 2012·Frontiers in Immunology·Jillian L AstaritaShannon J Turley
Jan 15, 2014·Cytokine & Growth Factor Reviews·Xiaoying ZhaoXiaoling Zhang
Apr 3, 2014·Physiological Reviews·Richard L EckertKapil Mehta
Jun 10, 2014·Journal of Proteome Research·Cecilia LindskogFredrik Pontén
Dec 4, 2014·Small GTPases·Natalie Ann Mack, Marios Georgiou

❮ Previous
Next ❯

Citations

Apr 1, 2018·Molecular Carcinogenesis·Qiao Yi ChenMax Costa
Sep 5, 2020·Journal of Cellular and Molecular Medicine·Sanjit K RoyRakesh K Srivastava
Oct 5, 2018·Journal of Cell Science·Varisa PongrakhananonPithi Chanvorachote

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.