Satellite cells: regenerative mechanisms and applicability in muscular dystrophy

Stem Cells International
Gustavo Torres de SouzaCarlos Magno da Costa Maranduba

Abstract

The satellite cells are long regarded as heterogeneous cell population, which is intimately linked to the processes of muscular recovery. The heterogeneous cell population may be classified by specific markers. In spite of the significant amount of variation amongst the satellite cell populations, it seems that their activity is tightly bound to the paired box 7 transcription factor expression, which is, therefore, used as a canonical marker for these cells. Muscular dystrophic diseases, such as Duchenne muscular dystrophy, elicit severe tissue injuries leading those patients to display a very specific pattern of muscular recovery abnormalities. There have been works on the application of precursors cells as a therapeutic alternative for Duchenne muscular dystrophy and initial attempts have proven the cells inefficient; however later endeavours have proposed solutions for the experiments improving significantly the results. The presence of a range of satellite cells populations indicates the existence of specific cells with enhanced capability of muscular recovery in afflicted muscles.

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Jan 27, 2016·Neuromuscular Disorders : NMD·Volker Straub, Marta Bertoli
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Jan 21, 2021·Clinical Epigenetics·Anna RugowskaPatryk Konieczny
May 1, 2021·International Journal of Molecular Sciences·Laura DobladoMaria Monsalve

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Methods Mentioned

BETA
electron microscopy
fluorescence-activated cell sorting
flow cytometry
transfection

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