Satellite heterophagosomes

Experientia
F N Ghadially, J M Lalonde

Abstract

An incidental observation made during a recent ultrastructural study shows that after ingestion of an erythrocyte by a Kupffer cell surface budding occurred from the heterophagosome leading to the formation of smaller satellite or daughter heterophagosomes. It is suggested that an entire erythrocyte may be too large to digest in a single heterolysosome and that fragmentation into smaller units facilitates digestion by bringing about better contact between the enzymes and substrates.

References

Sep 1, 1966·Annals of the Rheumatic Diseases·S Roy, F N Ghadially
Jan 1, 1966·Annual Review of Physiology·C De Duve, R Wattiaux

Citations

Sep 25, 1978·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M Djaldetti, N Feller

Related Concepts

Erythrocytes
Hepatic Macrophage
Phagocytosis

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