Satigrel, a new antiplatelet agent, inhibits platelet accumulation in prosthetic arterial grafts

American Journal of Surgery
K EsatoK Ishii

Abstract

Early and late vascular obstruction are both related to platelet adhesion and aggregation in the grafts. We assessed the effect of satigrel, a new oral antiplatelet agent, on the accumulation of indium-labeled platelets in knitted Dacron grafts inserted proximal to the femoral artery. Nine patients with arteriosclerosis obliterans receiving grafts were treated with satigrel, and 10 others were enrolled as untreated controls. Scintigraphy was performed in postoperative weeks 2 and 4, and the ratio of the scintillation count of the graft to that of the native artery was calculated to assess platelet accumulation. In both weeks 2 and 4, the ratio was significantly smaller in the satigrel group than in the control group for the whole graft, the proximal anastomosis, and the distal anastomosis. Satigrel significantly inhibited platelet accumulation in vascular grafts and thus may be useful for preventing postoperative graft occlusion.

Citations

Nov 30, 1999·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·K Esato
Oct 14, 2006·Vascular and Endovascular Surgery·Taro ShimazakiShin Ishimaru

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