Satisfaction and efficacy of switching from daily dipeptidyl peptidase-4 inhibitors to weekly trelagliptin in patients with type 2 diabetes-Randomized controlled study

Endocrine Journal
Mayuko OitaTatsuya Atsumi

Abstract

We compared treatment satisfaction between daily dipeptidyl peptidase-4 (DPP-4) inhibitors and a weekly DPP-4 inhibitor in patients with type 2 diabetes. The study was a 12-week, open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes who had received daily DPP-4 inhibitors for more than 3 months. Patients were randomly assigned to a treatment cohort: (1) a group that continued taking daily DPP-4 inhibitors (daily group); or (2) a group that switched from daily DPP-4 inhibitors to a weekly DPP-4 inhibitor, trelagliptin (weekly group). The primary outcome was the change in treatment satisfaction levels from baseline to 12 weeks between the two groups, according to Diabetes Treatment Satisfaction Questionnaire (DTSQ) and Diabetes Therapy-Related Quality of Life (DTR-QOL) questionnaire scores. The changes in glycemic control and body weight were also assessed. Of 49 patients initially enrolled in the study, 47 completed the study. The change in DTSQ scores in the weekly group was not significantly different from that in the daily group. However, the improvements in total score and subscale domains 1 and 2 in the DTR-QOL analysis, which relate to burden on social/daily activit...Continue Reading

References

Nov 25, 2004·Diabetes Care·Manel PladevallJennifer Elston Lafata
Mar 4, 2009·Family Practice·Aya BidermanAmalia Levy
Jul 4, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·J H BestM Peyrot
Jan 25, 2012·Patient Preference and Adherence·Carla Dias BarbosaDiana Rofail
Jan 29, 2016·Journal of Pharmaceutical Health Care and Sciences·Morihiro OkadaYoshimichi Sai
Apr 29, 2016·Journal of Managed Care & Specialty Pharmacy·Vishal SaundankarAnthony Louder
May 18, 2016·Journal of Diabetes Investigation·Yutaka SeinoDaisuke Yabe
Sep 13, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S GalassoD Bruttomesso
Mar 14, 2017·Diabetes & Metabolic Syndrome·Abdulbari BenerMustafa Öztürk

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