Satisfactory therapy results of combining nimustine with nicardipine against glioma at advanced stage

Journal of Cancer Research and Therapeutics
Meiqing Lou, Yaodong Zhao

Abstract

Glioblastoma multiforme (GBM) is one of the most frequent brain cancers with a very poor prognosis. According to cancer stem cell (CSC) theory, therapies that are more specifically directed against CSCs might result in much more durable responses. Recently, we treated a case of GBM basing on the conception of CSC and gained a better clinic outcome. A 37-year-old male patient complained weakness of left limbs for 1 month. Magnetic resonance imaging (MRI) showed extensive lesions in the right hemisphere. We performed an intracranial tumor partial resection and the postoperative pathological diagnose was GBM. 1 month later, he received monthly chemotherapies with the combination of nimustine and nicardipine for totally 4 times. At the last chemotherapy, MRI scan showed the cancer almost completely disappeared with significantly improved clinic condition. The combination therapy of chemotherapeutics and nicardipine may be a promising treatment for patients of GBM at advanced stage.

References

Jan 31, 2002·Annual Review of Medicine·Michael M Gottesman
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Apr 3, 2009·Journal of Cancer Research and Clinical Oncology·Yao JinLan Qing

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Citations

Jul 18, 2016·International Immunopharmacology·Bo ZengZhengquan Yu
Sep 15, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming TuWeiming Zheng
Dec 15, 2017·Neural Regeneration Research·Yao-Dong ZhaoQiang Huang
Jul 6, 2017·Oncology Reports·Xianghe LuWenfeng Li
Oct 5, 2016·Oncology Letters·Chunyang MaKun Yang

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