SATR-1 hypomethylation is a common and early event in breast cancer

Cancer Genetics and Cytogenetics
Fabrício F CostaAnamaria A Camargo

Abstract

Genome stability and normal gene expression are maintained by a fixed and predetermined DNA methylation pattern, which becomes abnormal in malignant cells. Hypomethylation of satellite DNA sequences is frequently found in tumors and has been associated with an increased frequency of DNA rearrangements and chromosome instability. In this work, we used methylation-sensitive arbitrarily primed polymerase chain reaction (MSAP-PCR) to identify differentially methylated DNA fragments in normal and tumor breast samples. We identified a novel differentially methylated fragment located on chromosome 5 with high similarity to a SATR-1 satellite sequence. This fragment was found to be hypomethylated in 63% of breast tumor cell lines and in 86% of breast tumors relative to normal breast tissue. We found that normal tissue adjacent to breast tumors displayed a variable decrease in methylation and that the decrease observed for most of these adjacent samples was higher than observed for normal breast tissue derived from reduction mammoplasty. The methylation decrease was, however, significantly higher in tumor samples than in adjacent tissue (chi2= 154, 1 df, P < 10(-4)), suggesting that SATR-1 hypomethylation frequently occurs in the early ...Continue Reading

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Citations

Mar 20, 2008·Journal of Human Genetics·Elias ZintzarasMichael Voulgarelis
Jan 27, 2010·Journal of Mammary Gland Biology and Neoplasia·Jürgen Veeck, Manel Esteller
Oct 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Marzena A LewandowskaAnn Harris
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Oct 12, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Sonia FabrisAndrea Baccarelli

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