Saturated fatty acids and LDL receptor modulation in humans and monkeys

Prostaglandins, Leukotrienes, and Essential Fatty Acids
K C HayesA Pronczuk

Abstract

It has been known for 40 years that dietary saturated fat (SAT FAT) increases plasma cholesterol, including LDL-C and HDL-C. In humans, where LDL-C is typically > 90 mg/dl this SAT FAT effect largely reflects changes in LDL-C pool size. The original human studies suggested that LDL-C expansion during SAT FAT consumption reflected reduced LDL clearance (LDL receptor activity) in hyperlipemics and increased LDL production rates in normolipemics (LDL-C < 100 mg/dl) . This dual explanation is supported by data from several animal models where specific saturated fatty acids (SFAs) have been the focus. However, the situation is complicated by the fact that polyunsaturated fatty acids (PUFAs) oppose SFAs, i.e. PUFAs decrease LDL-C and increase LDL receptor (LDLr) activity, so the effect of SAT FAT intake may represent the combined influence of increased SFAs and decreased PUFAs. In fact, careful scrutiny of primate data suggests a negligible effect of saturated fat on LDL clearance (and receptor activity) in the absence of dietary cholesterol when PUFA intake is adequate (5-10%en) and the lipoprotein profile is relatively normal (LDL-C < 90 mg/dl), i.e. normolipemic situations at the time of dietary intervention. In such cases increas...Continue Reading

References

May 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K C Hayes, P Khosla
Jan 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R J NicolosiE J Schaefer
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D K Spady, J M Dietschy
Apr 1, 1996·The Journal of Nutrition·K C Hayes, P Khosla

❮ Previous
Next ❯

Citations

Aug 17, 2010·Current Atherosclerosis Reports·Patty W Siri-TarinoRonald M Krauss
Feb 9, 2002·The Journal of Nutritional Biochemistry·Sebely PalPaul D. Roach
Nov 10, 2006·The British Journal of Nutrition·Maria José CaballeroMarisol Izquierdo
Mar 16, 2011·Journal of Agricultural and Food Chemistry·Sinead Eileen MilnerAnita Rose Maguire
May 27, 1999·The Proceedings of the Nutrition Society·M J Gibney
Jan 13, 2006·Critical Reviews in Food Science and Nutrition·J Bruce German, Cora J Dillard
Jan 22, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Nov 10, 2009·Progress in Lipid Research·R TakechiJ C L Mamo
May 23, 2008·The Journal of Nutritional Biochemistry·Moises Torres-GonzalezMaria Luz Fernandez
Mar 10, 2015·Computational and Structural Biotechnology Journal·Mark T Mc Auley, Kathleen M Mooney
Jul 20, 2007·Planta·Keren Hendel-RahmanimDavid Weiss
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kanta ChechiSukhinder K Cheema
Dec 30, 2004·Nutrition Reviews·Penny M Kris-EthertonAmy E Binkoski
Mar 22, 2006·The Journal of Nutrition·Thais B CésarRaul C Maranhão
May 27, 2021·The Journal of Nutrition·Carolina Donat-VargasPilar Guallar-Castillón

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.