Saturation diving alters folate status and biomarkers of DNA damage and repair.

PloS One
S R ZwartS M Smith

Abstract

Exposure to oxygen-rich environments can lead to oxidative damage, increased body iron stores, and changes in status of some vitamins, including folate. Assessing the type of oxidative damage in these environments and determining its relationships with changes in folate status are important for defining nutrient requirements and designing countermeasures to mitigate these effects. Responses of humans to oxidative stressors were examined in participants undergoing a saturation dive in an environment with increased partial pressure of oxygen, a NASA Extreme Environment Mission Operations mission. Six participants completed a 13-d saturation dive in a habitat 19 m below the ocean surface near Key Largo, FL. Fasting blood samples were collected before, twice during, and twice after the dive and analyzed for biochemical markers of iron status, oxidative damage, and vitamin status. Body iron stores and ferritin increased during the dive (P<0.001), with a concomitant decrease in RBC folate (P<0.001) and superoxide dismutase activity (P<0.001). Folate status was correlated with serum ferritin (Pearson r = -0.34, P<0.05). Peripheral blood mononuclear cell poly(ADP-ribose) increased during the dive and the increase was significant by the...Continue Reading

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Citations

Sep 22, 2012·Journal of Applied Physiology·Jennifer L L MorganScott M Smith
Sep 27, 2019·Occupational and Environmental Medicine·Yuan YuanZhenglin Jiang
Dec 24, 2019·Frontiers in Physiology·Damian ŁuczyńskiIngrid Eftedal
Dec 16, 2021·Revista da Associação Médica Brasileira·Ali Erdal GunesHakim Celik

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Methods Mentioned

BETA
blood draw
ELISA

Software Mentioned

SigmaStat
NEEMO

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