Saturation oxygenation pressure index: a non-invasive bedside measure for severity of respiratory disease in neonates on CPAP.

European Journal of Pediatrics
Deepti ThandaveshwaraSrinivasa M Doreswamy

Abstract

The treatment of respiratory distress in neonates ranges from non-invasive continuous positive airway pressure (CPAP) to advanced invasive mechanical ventilation. Monitoring on CPAP is often done by calculating oxygenation after blood gas analysis which is an invasive procedure. Saturation oxygen pressure index (SOPI) is a simple, non-invasive, bedside tool to monitor the severity of respiratory illness in neonates on CPAP. This study was aimed at validation of SOP index against AaDO2 and determine the cut-off values of SOPI for A-aDO2 of 70, 85 and100. This was a prospective observational study on 126 neonates with respiratory distress and treated with CPAP. The correlation between SOPI and A-aDO2 was validated using Bootstrap method. There was a significant positive correlation between SOPI and A-aDO2 with the Spearman correlation coefficient (rho) being 0.815 (p = 0). The mean coefficient of correlation after Bootstrap was 0.827 (p value < 0.0001). SOPI values of 1.52, 1.57 and 1.6 predicted A-aDO2 value of 70, 85 and 100 with a sensitivity of above 80% and specificity above 90%, respectively.Conclusion: SOPI has a significant positive correlation of 82.7% against A-aDO2 and can be a valuable tool to assess respiratory distr...Continue Reading

References

Sep 1, 1982·American Journal of Surgery·C A SoderstromR A Cowley
Feb 23, 2008·Journal of Applied Physiology·Andrew T LoveringMarlowe W Eldridge
Aug 23, 2011·Archives of Disease in Childhood. Fetal and Neonatal Edition·Claus KlingenbergCarl A Kuschel
Jan 17, 2015·Neonatology·Munmun RawatSatyan Lakshminrusimha
Jan 4, 2017·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Elizabeth SharpeVineet Chopra
May 26, 2017·Pediatrics and Neonatology·Maroun J MhannaMohit Jain

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