Saucerneol D inhibits dendritic cell activation by inducing heme oxygenase-1, but not by directly inhibiting toll-like receptor 4 signaling

Journal of Ethnopharmacology
Hwa Sun RyuSang-Bae Han

Abstract

Saururus chinensis is a medicinal plant used to treat jaundice, pneumonia, edema, fever, and several inflammatory diseases. Saucerneol D (SD), a lignan constituent of this plant, has antioxidant, anti-asthmatic, and anti-inflammatory activities. SD has been previously reported to inhibit the pro-inflammatory responses of RAW264.7 cells and primary mast cells. In this study, we investigated the effect of SD on the functions of dendritic cells (DCs). SD was isolated from methanol extract of the roots of S. chinensis. Bone marrow-derived DCs were used as target cells. The effects of SD on the following DC functions were examined: surface molecule expression, cytokine expression, migration, allogenic T cell activation, heme oxygenase-1 expression, and Toll-like receptor 4 signaling. In lipopolysaccharide (LPS)-treated DCs, SD inhibited the expression of cell surface molecules (MHC I/II, CD40, CD80, and CD86), the production of inflammatory mediators (nitric oxide, IL-12, IL-1β, and TNF-α), and allogenic T cell activation capacity. SD also inhibited DC migration toward MIP-3β by down-regulating CCR7 expression. SD attenuated LPS-induced activation of NF-κB and MAPK signaling in DCs, but did not directly inhibit kinase activities of ...Continue Reading

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Citations

Feb 14, 2020·Anti-cancer Agents in Medicinal Chemistry·Kanchana UsuwanthimThitiya Luetragoon
Jan 23, 2020·The American Journal of Chinese Medicine·Guangxin LiuCuiqin Li
Apr 1, 2016·Journal of Microscopy and Ultrastructure·Alia M Aldahlawi
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hwa Sun RyuYong-Moon Lee

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