Abstract
Saururus chinensis is a medicinal plant used to treat jaundice, pneumonia, edema, fever, and several inflammatory diseases. Saucerneol D (SD), a lignan constituent of this plant, has antioxidant, anti-asthmatic, and anti-inflammatory activities. SD has been previously reported to inhibit the pro-inflammatory responses of RAW264.7 cells and primary mast cells. In this study, we investigated the effect of SD on the functions of dendritic cells (DCs). SD was isolated from methanol extract of the roots of S. chinensis. Bone marrow-derived DCs were used as target cells. The effects of SD on the following DC functions were examined: surface molecule expression, cytokine expression, migration, allogenic T cell activation, heme oxygenase-1 expression, and Toll-like receptor 4 signaling. In lipopolysaccharide (LPS)-treated DCs, SD inhibited the expression of cell surface molecules (MHC I/II, CD40, CD80, and CD86), the production of inflammatory mediators (nitric oxide, IL-12, IL-1β, and TNF-α), and allogenic T cell activation capacity. SD also inhibited DC migration toward MIP-3β by down-regulating CCR7 expression. SD attenuated LPS-induced activation of NF-κB and MAPK signaling in DCs, but did not directly inhibit kinase activities of ...Continue Reading
References
Feb 1, 1996·Arthritis and Rheumatism·R Thomas, P E Lipsky
Sep 18, 1997·Immunology Today·V B Morhenn
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
Jul 22, 1998·The Journal of Experimental Medicine·M C DieuC Caux
Dec 10, 1998·Immunity·E A GreenR A Flavell
Sep 25, 1999·Journal of Neuroimmunology·Y M HuangH Link
Feb 9, 2000·The Journal of Experimental Medicine·R M SteinmanK Inaba
Apr 27, 2000·Immunology Today·H DrakesmithP Beverley
Dec 7, 2000·The American Journal of Pathology·B SerafiniF Aloisi
Sep 18, 2001·Chemical & Pharmaceutical Bulletin·S H SungY C Kim
Oct 19, 2001·International Immunopharmacology·S B HanH M Kim
Nov 17, 2001·Science·P BlancoJ Banchereau
Sep 19, 2003·Phytochemistry·Bang Yeon HwangJung Joon Lee
Dec 23, 2003·The Journal of Biological Chemistry·Daniel MartinAntonio Cuadrado
Feb 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nobunao WakabayashiPaul Talalay
Feb 24, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kenichiro YamashitaFritz H Bach
Sep 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Weizheng W WangStephen D Zucker
Sep 13, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judit K Sarady-AndrewsLeo E Otterbein
Oct 26, 2005·Biochemical and Biophysical Research Communications·Jian WuTung-Yu Tsui
Nov 17, 2005·Physiology·Mahin D Maines
Mar 21, 2006·Immunity·Jeffrey A BluestoneLaurence A Turka
May 11, 2006·Blood·Sergio RutellaGiuseppe Leone
Aug 5, 2006·The EMBO Journal·Shih-Ching LoMark Hannink
Dec 13, 2006·International Immunopharmacology·Jee Youn KimSang-Bae Han
Dec 21, 2006·Cancer Research·Tin Oo KhorAh-Ng Kong
Jun 26, 2007·Nature Reviews. Immunology·José A Villadangos, Petra Schnorrer
Feb 29, 2008·Cytokine·Yong-Chen LuPamela S Ohashi
Dec 17, 2008·Recent Patents on Inflammation & Allergy Drug Discovery·Hyun-Ock PaeHun-Taeg Chung
Nov 7, 2009·Journal of Biomedical Science·Yuanbin Liu, David R Schubert
Nov 10, 2009·Archives of Pharmacal Research·Yeun-Kyung LeeJong-Keun Son
Jan 12, 2010·The International Journal of Biochemistry & Cell Biology·Marene Landström
Jul 6, 2010·Biochemical Pharmacology·Sinead Flannery, Andrew G Bowie
Feb 3, 2011·Immune Network·Hyung Sook KimSang-Bae Han
Feb 8, 2011·International Immunopharmacology·Ju-Young JungHwa-Young Son
Sep 13, 2011·Archives of Pharmacal Research·Ji Young YunYoungsoo Kim
Oct 28, 2011·Trends in Immunology·Clare L Bennett, Ronjon Chakraverty
Mar 6, 2012·Biochemical and Biophysical Research Communications·Sun Hong ParkYoungsoo Kim
Sep 4, 2012·IUBMB Life·Liang DaiPeter C F Cheung
Sep 18, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yue LuHyeun Wook Chang
Feb 12, 2013·Environmental Toxicology and Pharmacology·Mei Ling JinSang Joon Lee
Jan 1, 2014·Acta Pharmacologica Sinica·Ben-ping ZhangJun Fang
Aug 6, 2014·International Immunopharmacology·Yunsoo ParkSang-Bae Han
Citations
Jan 17, 2016·International Immunopharmacology·Ji-Won SongHwa-Young Son
Jun 29, 2016·International Immunopharmacology·Chao GuoLingyi Kong
Nov 11, 2015·Experimental Biology and Medicine·Xue MengSe Chan Kang
Jan 25, 2017·Scientific Reports·Hong Kyung LeeSang-Bae Han
Feb 14, 2020·Anti-cancer Agents in Medicinal Chemistry·Kanchana UsuwanthimThitiya Luetragoon
Jan 6, 2019·Archives of Pharmacal Research·Yeon Woo JungByung Sun Min
Jan 23, 2020·The American Journal of Chinese Medicine·Guangxin LiuCuiqin Li
Apr 1, 2016·Journal of Microscopy and Ultrastructure·Alia M Aldahlawi
Dec 3, 2020·Antioxidants·Dongyup HahnJong Sup Bae
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie RenKun Hu
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hwa Sun RyuYong-Moon Lee
May 13, 2021·Phytotherapy Research : PTR·Xin-Xing LiHongwei Gao