Saving more teeth-a case for personalized care

Journal of Personalized Medicine
Alexandre R VieiraThomas W Braun

Abstract

Certain risk factors such as tobacco use, diabetes, genetic variations on the IL1 gene, and other inflammatory conditions are hypothesized to predict tooth loss in patients treated in a large medical center. Tooth loss trends are hypothesized to be greater in patients with more risk factors. DNA samples for 881 individuals were taken from the Dental Registry and DNA Repository at University of Pittsburgh School of Dental Medicine. Clinical data for all 4137 subjects in the registry were also available. SNP genotyping was performed on the samples for IL1α (rs1800587) and IL1β (rs1143634). IL1 positive status was determined as having one or more of the recessive alleles for either SNP. Tooth loss status was determined based on dental records and data gathered for age, sex, ethnicity, and self-reported medical history. Various statistical analyses were performed on the data including genetic association analysis by the PLINK software, chi-square, Mann-Whitney U, and ANOVA tests to determine significance. Tooth loss averages increased with age by all risk factors (smoking, diabetes, hypertension, and interleukin genotypes; p = 4.07E-13) and by number of risk factors (p = 0.006). Increased tooth loss is associated with age and numbe...Continue Reading

References

Jan 3, 2009·The Journal of the American Dental Association·Renato MenezesAlexandre Rezende Vieira
Sep 24, 2010·Journal of Community Health·Elizabeth L McGarveyWendy F Cohn
Jun 12, 2013·Journal of Dental Research·W V GiannobileK S Kornman

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Citations

Mar 24, 2016·International Journal of Dentistry·Andrew J Ng, Alexandre R Vieira
Nov 6, 2018·Clinical Oral Investigations·Indiara W HennAlexandre R Vieira
Apr 22, 2019·Journal of Clinical Periodontology·Lauren Williams-Wiles, Alexandre R Vieira
May 31, 2020·Journal of Personalized Medicine·Alexandre R VieiraAdriana Modesto
Jun 12, 2019·Journal of Dental Education·Linda Y ZhengSteven D London
Aug 10, 2017·International Journal of Dentistry·John K Drisdale IiiAlexandre R Vieira
Oct 19, 2016·Journal of Clinical Periodontology·Luigi NibaliAlexandre R Vieira
Mar 19, 2020·Scientific Reports·Mariana BezamatAlexandre R Vieira
Dec 14, 2019·Scientific Reports·Letícia Chaves de SouzaAriadne Letra
Jan 6, 2021·Journal of Personalized Medicine·Ariana M KellyAlexandre R Vieira

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Software Mentioned

PLINK

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