PMID: 11913955Mar 27, 2002Paper

Saw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells

Cell Biology International
W H GoldmannC P Sharma

Abstract

The cytotoxicity of a commonly used material to alleviate the symptoms of benign prostatic hyperplasia (BPH), Saw Palmetto Berry Extract (SPBE), was examined as neat oil using a set of prostatic cell lines; 267B-1, BRFF-41T and LNCaP. Proliferation of these prostatic derived cell lines is inhibited to different degrees when dosed for 3 days with SPBE. The amount of SPBE required to inhibit 50% growth (IC50) of these cell lines was 20-30 nl equivalents of SPBE per ml of medium for cell lines 267B-1 and BRFF-41T and approximately 10-fold more for the LNCaP cell line. The effect of SPBE dosing on these cell lines is not irreversible, since a 30 min treatment with SPBE at an IC50 concentration does not inhibit their growth. Normal prostate cells were inhibited by 20-25% when grown in the presence of 200 nl SPBE equivalent per ml media. Growth of other non-prostatic cancer cell lines, i.e. Jurkat and HT-29, was affected by approx. 50% and 40%, respectively. When LNCaP cells were grown in the presence of dihydrotestosterone and SPBE, the IC50 concentration decreased significantly compared to LNCaP cells grown in the presence of serum and SPBE. Reduced cellular growth after SPBE treatment of these cell lines may relate to decreased ex...Continue Reading

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Mar 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·S DélosJ P Raynaud
Jan 1, 1995·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P Vacher
Feb 19, 1998·Medical Oncology·P GuinanM Rubenstein
Sep 17, 1998·The New England Journal of Medicine·R S DiPaolaM A Gallo

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Citations

Nov 28, 2012·Journal of Natural Medicines·Nicole VillaverdeM Alejandro Barbieri
Apr 19, 2006·Current Oncology Reports·Debra L BemisRalph Buttyan
Apr 25, 2006·Current Urology Reports·Debra L BemisRalph Buttyan
Aug 26, 2006·Current Urology Reports·Andrew L Avins, Stephen Bent
Dec 3, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·José A Olalde RangelOswaldo del Castillo
Mar 22, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·Lynn S AdamsDavid Heber
Aug 27, 2011·Journal of Medical Case Reports·Jackrapong BruminhentIngram M Roberts
Sep 24, 2014·Prostate Cancer and Prostatic Diseases·T B DorffJ K Pinski
Mar 15, 2011·Journal of Ethnopharmacology·Pedro A V Reis de SouzaLuiz E Nasciutti
Jan 1, 2009·Environmental Toxicology and Pharmacology·Wachareeporn TrinachartvanitA Lane Rayburn
Jan 24, 2006·Clinical Genitourinary Cancer·Raj S Pruthi, Eric M Wallen
Apr 21, 2012·Phytotherapy Research : PTR·Kazuya MurataHideaki Matsuda
May 9, 2003·The Urologic Clinics of North America·Barrie R Cassileth, Andrew J Vickers
Jun 9, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Alexander B Opoku-AcheampongBrian L Lindshield
Aug 17, 2016·International Journal of Molecular Sciences·Hor-Yue TanYibin Feng
Sep 13, 2006·Nutrition and Cancer·Raven M Bonnar-PizzornoEmily White
Aug 30, 2007·Phytotherapy Research : PTR·Priyadarshini RamanMuraleedharan G Nair
Sep 8, 2009·Bioscience, Biotechnology, and Biochemistry·Kiichiro AkamineKazunaga Yazawa
Dec 12, 2003·Nature Reviews. Cancer·Peter S Nelson, Bruce Montgomery
Dec 1, 2020·Natural Product Research·Seham S El-HawwaryUsama Ramadan Abdelmohsen

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