Say no to drugs: Bioactive macromolecular therapeutics without conventional drugs.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Marie RütterAyelet David

Abstract

The vast majority of nanomedicines (NM) investigated today consists of a macromolecular carrier and a drug payload (conjugated or encapsulated), with a purpose of preferential delivery of the drug to the desired site of action, either through passive accumulation, or by active targeting via ligand-receptor interaction. Several drug delivery systems (DDS) have already been approved for clinical use. However, recent reports are corroborating the notion that NM do not necessarily need to include a drug payload, but can exert biological effects through specific binding/blocking of important target proteins at the site of action. The seminal work of Kopeček et al. on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing biorecognition motifs (peptides or oligonucleotides) for crosslinking cell surface non-internalizing receptors of malignant cells and inducing their apoptosis, without containing any low molecular weight drug, led to the definition of a special group of NM, termed Drug-Free Macromolecular Therapeutics (DFMT). Systems utilizing this approach are typically designed to employ pendant targeting-ligands on the same macromolecule to facilitate multivalent interactions with receptors. The lack of conventional small...Continue Reading

References

Oct 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y C Lee
Jul 1, 1996·Analytical Biochemistry·G Weitz-SchmidtN V Bovin
Jul 20, 1999·The Journal of Clinical Investigation·A AshkenaziR H Schwall
Sep 15, 2001·Journal of Biomaterials Science. Polymer Edition·K MerrettH Sheardown
Dec 18, 2001·Medicinal Research Reviews·Jian Liu, Suzanne C Thorp
Dec 18, 2001·Journal of Neuroscience Research·S WoerlyJ D Peduzzi
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kiyotaka NishikawaYasuhiro Natori
Oct 18, 2002·Immunology·Julie P DeansMaria J Polyak
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Fátima LasalaRafael Delgado
Dec 5, 2003·Trends in Pharmacological Sciences·Holger UlbrichLennart Lindbom
Jan 6, 2004·Journal of Neuroscience Research·Stéphane WoerlyAraceli Espinosa-Jeffrey
Jan 28, 2004·The Journal of Infectious Diseases·Miho WatanabeKiyotaka Nishikawa
Mar 6, 2004·Glycoconjugate Journal·T V PochechuevaN V Bovin
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·S BouralexisA Evdokiou
May 18, 2005·The International Journal of Biochemistry & Cell Biology·Mike Bray, Thomas W Geisbert
Jul 21, 2005·Journal of the American Chemical Society·Shyam M ReleElliot L Chaikof
Dec 27, 2005·Experimental Cell Research·Judah Folkman
May 26, 2006·Nature Reviews. Cancer·Patrick Mehlen, Alain Puisieux
Feb 20, 2007·Current Medicinal Chemistry·Hanako KobayashiP Charles Lin
Feb 5, 2008·The Journal of Allergy and Clinical Immunology·C Wayne Smith
Sep 12, 2008·Clinical Pharmacology and Therapeutics·W WangJ P Balthasar
Sep 10, 2009·Clinical and Experimental Immunology·E MartinelliF Ciardiello
Sep 15, 2009·Journal of Medicinal Chemistry·Yosi ShamayAyelet David
Nov 19, 2009·Advanced Drug Delivery Reviews·Jindrich Kopecek, Pavla Kopecková
Jan 28, 2010·Cancer Research·Valeria PavetHinrich Gronemeyer
Apr 24, 2010·Nature Reviews. Immunology·Louis M WeinerShangzi Wang
Sep 3, 2010·Nature Reviews. Drug Discovery·Aaron L NelsonJanice M Reichert
Oct 12, 2010·Journal of the American Chemical Society·C Remzi BecerDavid M Haddleton
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jens DerneddeRainer Haag
Mar 9, 2011·Chembiochem : a European Journal of Chemical Biology·Ilona PappRainer Haag
Aug 17, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kuangshi WuJindřich Kopeček
May 15, 2012·Current Opinion in Pharmacology·Lun K TsouYung-Chi Cheng

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Citations

May 20, 2021·Macromolecular Bioscience·Marina Rodrigues TavaresTomáš Etrych
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·M Tommy GamblesJindřich Kopeček

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