SB209670, a potent endothelin receptor antagonist, prevents or delays axonal degeneration after spinal cord injury

Brain Research
M UesugiK Goto

Abstract

We developed a rat spinal cord transection injury model and investigated whether endogenous endothelin takes part in axonal degeneration after injury, by using a potent nonselective endothelin receptor antagonist, SB209670. Light microscopic analysis showed that axonal degeneration of the spinal cord was clearly observed one week after injury, supported by immunohistochemical study with anti-neurofilament antibody. Electron microscopic observation showed enlargement and shrinking of spinal axons in the injured sites one week after injury. Application of SB209670 to the lesion sites markedly inhibited axonal damage after injury. These results suggest that endogenous endothelin plays a role in axonal degeneration after spinal cord injury and that SB209670 prevents or delays the axonal degeneration after CNS damage.

References

Mar 1, 1992·Trends in Pharmacological Sciences·T SakuraiT Masaki
Jul 15, 1992·Biochemical and Biophysical Research Communications·H HamaK Goto
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W MacCumberS H Snyder
Mar 1, 1990·Stroke; a Journal of Cerebral Circulation·R N WilletteE H Ohlstein
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·E H OhlsteinJ S Frazee
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I M MacraeJ McCulloch
Dec 1, 1996·Japanese Journal of Pharmacology·K GotoY Kasuya

❮ Previous
Next ❯

Citations

Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·S Thomas Carmichael
Dec 1, 2011·Translational Stroke Research·Richard L Benton, Theo Hagg
Oct 23, 2019·International Journal of Molecular Sciences·Sarah Lunardi Baccetto, Christian Lehmann
Aug 10, 2021·The EPMA Journal·Adriana Torres CrignaOlga Golubnitschaja

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Amy C Y LoSookja K Chung
Clinical Chemistry and Laboratory Medicine : CCLM
T BertschK Fassbender
Optometry and Vision Science : Official Publication of the American Academy of Optometry
Kwok Hei MokKwok Fai So
© 2022 Meta ULC. All rights reserved