SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool.

BMC Bioinformatics
Z ZiEdda Klipp

Abstract

It has long been recognized that sensitivity analysis plays a key role in modeling and analyzing cellular and biochemical processes. Systems biology markup language (SBML) has become a well-known platform for coding and sharing mathematical models of such processes. However, current SBML compatible software tools are limited in their ability to perform global sensitivity analyses of these models. This work introduces a freely downloadable, software package, SBML-SAT, which implements algorithms for simulation, steady state analysis, robustness analysis and local and global sensitivity analysis for SBML models. This software tool extends current capabilities through its execution of global sensitivity analyses using multi-parametric sensitivity analysis, partial rank correlation coefficient, SOBOL's method, and weighted average of local sensitivity analyses in addition to its ability to handle systems with discontinuous events and intuitive graphical user interface. SBML-SAT provides the community of systems biologists a new tool for the analysis of their SBML models of biochemical and cellular processes.

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Citations

May 7, 2010·Bioinformatics·Maria Rodriguez-Fernandez, Julio R Banga
Jan 26, 2010·Journal of the Royal Society, Interface·Natalja Strelkowa, Mauricio Barahona
Mar 17, 2011·BMC Systems Biology·Thanneer M Perumal, Rudiyanto Gunawan
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Apr 19, 2021·Mathematical Biosciences·Marissa RenardyDenise E Kirschner

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Methods Mentioned

BETA
pull down

Software Mentioned

CellDesigner
libSBML
SOBOL
SBMLeditor
SBTOOLBOX2
COPASI
BioModels
Matlab
MPSA
Windows

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