SC1/hevin identifies early white matter injury after ischemia and intracerebral hemorrhage in young and aged rats

Journal of Neuropathology and Experimental Neurology
Starlee Lively, Lyanne C Schlichter

Abstract

The progression of white matter damage after ischemic and hemorrhagic strokes can exacerbate the initial injury, but little is known about the processes involved. We show that the antiadhesive matricellular glycoprotein SC1 is a novel early marker of white matter damage in 3 models of acute injury in the rat striatum: transient focal ischemia, intracerebral hemorrhage, and a needle penetration wound. SC1 was restricted to the damaged portions of axon bundles that bordered stroke lesions in young-adult and aged rats. SC1 peaked at 1 and 3 days after intracerebral hemorrhage and at 7 days after ischemia. The SC1-positive bundles usually expressed degraded myelin basic protein and amyloid precursor protein, a marker of axonal injury. At the hematoma edge, SC1 was seen in a few axon bundles that retained myelin basic protein staining. In these bundles, punctate SC1 staining filled individual axons, extended beyond a core of pan-axonal neurofilament and NF200 and was inside or overlapped with myelin basic protein staining when it was present. Aged rats had less SC1 (and amyloid precursor protein) after both types of stroke, suggesting a reduced axonal response. SC1 also labeled amyloid precursor protein-positive axon bundles along t...Continue Reading

References

Dec 1, 1991·Stroke; a Journal of Cerebral Circulation·N FutrellC Millikan
May 1, 1990·Stroke; a Journal of Cerebral Circulation·G A RosenbergM Kornfeld
Nov 1, 1988·Journal of Electron Microscopy Technique·C R Gerfen
Oct 15, 1993·Brain Research. Developmental Brain Research·M OhtaJ Tateishi
Jan 1, 1995·Acta Neuropathologica·S M GentlemanD I Graham
Jan 1, 1996·Free Radical Biology & Medicine·G M LackmannU Töllner
Dec 1, 1996·Stroke; a Journal of Cerebral Circulation·M R Del BigioJ Peeling
Mar 1, 1997·Brain : a Journal of Neurology·B FergusonV H Perry
Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K MatsushitaE H Lo
May 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A KharlamovD M Armstrong
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Sep 10, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eileen McCrackenJames McCulloch
Dec 19, 2002·Neurosurgery Clinics of North America·Christopher T Skidmore, John Andrefsky
Feb 5, 2003·Brain : a Journal of Neurology·I M Medana, M M Esiri
Jun 5, 2003·Annals of Neurology·Christopher PowerJames Peeling
Jul 5, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I BadanA Popa-Wagner
Apr 13, 2004·Current Opinion in Critical Care·Fred Rincon, Stephan A Mayer
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·Ye GongGuohua Xi
Oct 14, 2005·The Journal of Head Trauma Rehabilitation·Douglas H SmithWilliam H Shull
Jan 6, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Crystal L MacLellanFrederick Colbourne
Nov 2, 2006·Journal of Neurochemistry·Kinga SzydlowskaBozena Kaminska
Dec 8, 2006·Neurochemical Research·Starlee LivelyIan R Brown
Jun 20, 2007·Neurochemistry International·Alan S Hazell
Aug 30, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lizhen LiMilos Pekny
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Oct 14, 2008·Experimental Neurology·Jason K Wasserman, Lyanne C Schlichter
Nov 1, 2008·The European Journal of Neuroscience·Jason K WassermanLyanne C Schlichter
Dec 17, 2008·Cerebral Cortex·Toru TakahataTetsuo Yamamori
Feb 20, 2009·Nature·Anatoly NikolaevMarc Tessier-Lavigne
Sep 22, 2009·Journal of the Neurological Sciences·Yannick BéjotMaurice Giroud

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Citations

Feb 20, 2014·Neural Plasticity·Emma V Jones, David S Bouvier
Jul 1, 2016·Somatosensory & Motor Research·Naoya HashimotoHiroyuki Ichikawa
Sep 17, 2016·Journal of Neuropathology and Experimental Neurology·Starlee LivelyLyanne C Schlichter
Oct 5, 2019·CNS Neuroscience & Therapeutics·Neeraj ChaudharyGuohua Xi
Jun 25, 2020·International Journal of Molecular Sciences·Li LiXu Cui
Jul 7, 2017·BioMed Research International·Shilun ZuoHua Feng
Oct 4, 2019·CNS Neuroscience & Therapeutics·Yi-Bin JiangRong Hu
Jun 29, 2021·Frontiers in Neurology·Xiongjie FuGao Chen

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