Scaffold-based Drug Delivery for Cartilage Tissue Regeneration

Current Pharmaceutical Design
K T Shalumon, Jyh-Ping Chen

Abstract

Regenerative engineering is an advanced field comprising the collective benefit of biodegradable polymers with cells and tissue inducing factors. Current method of replacing the defective organ is through transplantation, but is limited due to immune rejection and availability. As a solution, new polymeric biomaterial-based three-dimensional (3D) scaffolds in combination with cells and inducing factors were aroused to fulfil the existing demands. These scaffolds apply material science, biomedical technology and translational medicine to develop functional tissue engineering constructs. Presence of small molecules and growth factors guides the cell phenotypes to specific organ development. The 3D scaffold thus could also be favorably used as carriers for various types of drugs and genes, with the release profile fine-tuned by modulation of the scaffold's morphology, porosity, and composition. An increasing trend was observed in recent years toward the combination of scaffolds and growth factors to fabricate a bioactive system, which not only provide a biomimetic biodegradable physical support for tissue growth but also explores biological signals to modulate tissue regeneration. In this review, along with general aspects of tiss...Continue Reading

Citations

Jan 5, 2017·Connective Tissue Research·Ana Rey-RicoHenning Madry
Aug 8, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Qingqing YaoYong Liu
Nov 24, 2016·Chemistry : a European Journal·Simona BettiniLudovico Valli
Jul 30, 2019·Frontiers in Chemistry·Yu ZhuangHongbo Yu

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