Scaffold-free Tissue Formation Under Real and Simulated Microgravity Conditions

Basic & Clinical Pharmacology & Toxicology
Ganna AleshchevaDaniela Grimm

Abstract

Scaffold-free tissue formation in microgravity is a new method in regenerative medicine and an important topic in Space Medicine. In this MiniReview, we focus on recent findings in the field of tissue engineering that were observed by exposing cells to real microgravity in space or to devices simulating to at least some extent microgravity conditions on Earth (ground-based facilities). Under both conditions - real and simulated microgravity - a part of the cultured cells of various populations detaches from the bottom of a culture flask. The cells form three-dimensional (3D) aggregates resembling the organs from which the cells have been derived. As spaceflights are rare and extremely expensive, cell culture under simulated microgravity allows more comprehensive and frequent studies on the scaffold-free 3D tissue formation in some aspects, as a number of publications have proven during the last two decades. In this MiniReview, we summarize data from our own studies and work from various researchers about tissue engineering of multi-cellular spheroids formed by cancer cells, tube formation by endothelial cells and cartilage formation by exposing the cells to ground-based facilities such as the 3D Random Positioning Machine (RPM)...Continue Reading

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Citations

Mar 30, 2018·Stem Cells and Development·Daniela GrimmAlamelu Sundaresan
Feb 20, 2020·International Journal of Molecular Sciences·Trine Engelbrecht HybelSascha Kopp
Jan 17, 2019·Current Drug Discovery Technologies·Martin Braddock
Apr 5, 2017·Scientific Reports·Danilo RanieriMaria Rosaria Torrisi
May 30, 2019·International Journal of Molecular Sciences·Marcus KrügerDaniela Grimm
Apr 30, 2020·International Journal of Molecular Sciences·Xiao LinAirong Qian
Mar 27, 2020·International Journal of Molecular Sciences·Johann Bauer
Dec 30, 2016·Basic & Clinical Pharmacology & Toxicology·Kim Brøsen
Dec 14, 2018·International Journal of Molecular Sciences·Sascha KoppDaniela Grimm
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Mar 2, 2019·In Vitro Cellular & Developmental Biology. Animal·Banglian DengJun Chen
Mar 8, 2020·International Journal of Molecular Sciences·Thomas J BauerDaniela Grimm
Oct 9, 2020·International Journal of Molecular Sciences·Mohamed Zakaria NassefMarcus Krüger
Dec 2, 2020·International Journal of Molecular Sciences·Alessandra CazzanigaJeanette A Maier
Jul 20, 2021·Frontiers in Cell and Developmental Biology·Jayashree SahanaDaniela Grimm

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