Scaffolded amino acids as a close structural mimic of type-3 copper binding sites

Chemical Communications : Chem Comm
H Bauke AlbadaRob M J Liskamp


We report the use of triazacyclophane (TAC)-scaffolded amino acids as a structural mimic for 3-histidine metal-binding sites in metalloproteins, especially for the mimicry of type-3 copper binding sites as are present in hemocyanin, tyrosinase and catechol oxidase.


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