Scaffolding the retina: the interstitial extracellular matrix during rat retinal development

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Linnéa TaylorFredrik Ghosh

Abstract

To examine the expression of interstitial extracellular matrix components and their role during retinal development. Fibronectin (FN), collagen IV (Coll IV) and laminin 5 (Lam 5) expression in rat retinas from developmental stages E17 to adult were studied. In addition, PN5 full-thickness retinas were cultured for 7 days with dispase, which selectively cleaves FN and Coll IV, at either 0.5 U/ml or 5.0 U/ml for 3 or 24h. Eyecups and retinal cultures were examined morphologically using hematoxylin and eosin staining and immunohistochemistry. Coll IV, Lam 5 and FN were all transiently expressed in the interstitial matrix of the retinal layers during development. The retinal layers in dispase treated explants was severely disturbed in a dose and time dependent manner. FN, Lam 5 and Coll IV, are present in the interstitial extracellular matrix during rat retinal development. Enzymatic cleavage of FN and Coll IV early in the lamination process disrupts the retinal layers implicating their pivotal role in this process.

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Citations

Jan 26, 2016·Molecular and Cellular Neurosciences·Marbella Chavez-SolanoMonica Lamas
May 22, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Azadeh SepahvandiFathollah Moztarzadeh
Aug 9, 2016·Molecular and Cellular Neurosciences·Marina Castro ZalisUlrica Englund Johansson
Nov 1, 2016·Experimental Biology and Medicine·Charles G MillerJean E Schwarzbauer
Nov 6, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ouafa SijilmassiAurora Del Río Sevilla
Nov 27, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Kristin AllanAlex Yuan
Aug 16, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Arwin ShresthaKristan S Worthington

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