Scaffolds based therapy for osteochondral lesions of the talus: A systematic review

World Journal of Orthopedics
Yoshiharu ShimozonoJohn G Kennedy

Abstract

To clarify the effectiveness of scaffold-based therapy for osteochondral lesions of the talus (OLT). A systematic search of MEDLINE and EMBASE databases was performed during August 2016 and updated in January 2017. Included studies were evaluated with regard to the level of evidence (LOE) and quality of evidence (QOE) using the Modified Coleman Methodology Score. Variable reporting outcome data, clinical outcomes, and the percentage of patients who returned to sport at previous level were also evaluated. Twenty-eight studies for a total of 897 ankles were included; 96% were either LOE III or IV. Studies were designated as either of poor or fair quality. There were 30 treatment groups reporting six different scaffold repair techniques: 13 matrix-induced autologous chondrocyte transplantation (MACT), nine bone marrow derived cell transplantation (BMDCT), four autologous matrix-induced chondrogeneis (AMIC), and four studies of other techniques. The categories of general demographics (93%) and patient-reported outcome data (85%) were well reported. Study design (73%), imaging data (73%), clinical variables (49%), and patient history (30%) were also included. The weighted mean American Orthopaedic Foot and Ankle Society (AOFAS) scor...Continue Reading

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Citations

Nov 6, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Christoph BecherHajo Thermann
Jul 21, 2020·International Journal of Sports Medicine·Yongxing CaoXiangyang Xu
Nov 23, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Matteo GuelfiJordi Vega
May 18, 2020·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Brijesh AyyaswamyRajiv Limaye
Sep 4, 2021·Journal of the American Podiatric Medical Association·Fatih DoğarAhmet Güney
Oct 6, 2021·Operative Orthopädie und Traumatologie·Stephanie GeyerAndrea E Achtnich

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