Scaffolds for hand tissue engineering: the importance of surface topography

The Journal of Hand Surgery, European Volume
E KloczkoLara Yildirimer

Abstract

Tissue engineering is believed to have great potential for the reconstruction of the hand after trauma, congenital absence and tumours. Due to the presence of multiple distinct tissue types, which together function in a precisely orchestrated fashion, the hand counts among the most complex structures to regenerate. As yet the achievements have been limited. More recently, the focus has shifted towards scaffolds, which provide a three-dimensional framework to mimic the natural extracellular environment for specific cell types. In particular their surface structures (or topographies) have become a key research focus to enhance tissue-specific cell attachment and growth into fully functioning units. This article reviews the current understanding in hand tissue engineering before focusing on the potential for scaffold topographical features on micro- and nanometre scales to achieve better functional regeneration of individual and composite tissues.

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Citations

Jun 24, 2015·The Journal of Hand Surgery, European Volume·Grey Giddins
Aug 13, 2015·The Journal of Hand Surgery, European Volume·R WongJ K F Wong
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Dec 20, 2018·Journal of Cellular Physiology·Bharath Kumar VelmuruganRathinasamy Baskaran

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Methods Mentioned

BETA
xenografts
biopsy

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