Scaffolds for peripheral nerve repair and reconstruction

Experimental Neurology
Sheng YiXiaosong Gu

Abstract

Trauma-associated peripheral nerve defect is a widespread clinical problem. Autologous nerve grafting, the current gold standard technique for the treatment of peripheral nerve injury, has many internal disadvantages. Emerging studies showed that tissue engineered nerve graft is an effective substitute to autologous nerves. Tissue engineered nerve graft is generally composed of neural scaffolds and incorporating cells and molecules. A variety of biomaterials have been used to construct neural scaffolds, the main component of tissue engineered nerve graft. Synthetic polymers (e.g. silicone, polyglycolic acid, and poly(lactic-co-glycolic acid)) and natural materials (e.g. chitosan, silk fibroin, and extracellular matrix components) are commonly used along or together to build neural scaffolds. Many other materials, including the extracellular matrix, glass fabrics, ceramics, and metallic materials, have also been used to construct neural scaffolds. These biomaterials are fabricated to create specific structures and surface features. Seeding supporting cells and/or incorporating neurotrophic factors to neural scaffolds further improve restoration effects. Preliminary studies demonstrate that clinical applications of these neural s...Continue Reading

Citations

Jul 31, 2019·Biomaterials Science·A AlessandrinoG Freddi
Oct 24, 2019·Biomaterials Science·Cristiana R CarvalhoJoaquim M Oliveira
Jul 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Maliheh JahromiAbbas Bakhtiari
Jun 13, 2020·Molecular and Cellular Biochemistry·Zhangchun ChengJianghong He
Dec 12, 2018·Neural Regeneration Research·Pei-Xun ZhangBao-Guo Jiang
Aug 29, 2020·Journal of Biomedical Materials Research. Part a·Nazanin GhaneSeeram Ramakrishna
Nov 13, 2020·Frontiers in Bioengineering and Biotechnology·Benedetta E FornasariStefania Raimondo
Mar 7, 2021·Nanomaterials·Olga Y AntonovaYuri M Shlyapnikov
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Meng ZhangPei-Xun Zhang
Jul 6, 2019·ACS Chemical Neuroscience·Shadi HoushyarRobert Shanks
Aug 31, 2021·Oxidative Medicine and Cellular Longevity·Rui LiYongsheng Jiang
Nov 4, 2021·CNS Neuroscience & Therapeutics·Yi-Jun LiuYan-Hua Wang

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