Dec 24, 2013

Scalability and in vivo validation of a multiscale numerical model of the left coronary circulation

American Journal of Physiology. Heart and Circulatory Physiology
Jonathan P MynardJoseph J Smolich

Abstract

Multiscale modeling is a promising tool for the study of coronary hemodynamics. A key strength of this approach is that it accounts for microvascular properties and extravascular forces that differ regionally and transmurally, as well as wave propagation effects in the conduit arteries. However, little validation of such models has been reported and no models of the newborn coronary circulation have been described. We therefore validated a multiscale model of the left coronary circulation using high-fidelity data from nine adult sheep and nine newborn lambs and investigated whether wave propagation effects are more prominent in adults, whose body size (and hence wave transit distance) is greater. The model consisted of a one-dimensional (1D) network of the major conduit arteries and a lumped parameter model of microvascular beds. Intramyocardial pressure was considered to arise via contraction-related myocyte thickening and transmission of ventricular cavity pressure into the heart wall. 1D network geometry from published human anatomical data was scaled using myocardial weights, while subject-specific aortic pressure/flow and ventricular pressure formed model inputs. Total vascular resistance was determined iteratively from me...Continue Reading

  • References43
  • Citations14

References

  • References43
  • Citations14

Citations

Mentioned in this Paper

Coronary Circulation
Arterial System
Blood Flow Velocity
Vascular Resistance
Muscle Cells
Diastolic Blood Pressure
Contraction (Finding)
Myocardium
Gastroschisis
Cavity of Ventricle

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