Scalable, divergent synthesis of meroterpenoids via "borono-sclareolide"

Journal of the American Chemical Society
Darryl D DixonPhil S Baran

Abstract

A scalable, divergent synthesis of bioactive meroterpenoids has been developed. A key component of this work is the invention of "borono-sclareolide", a terpenyl radical precursor that enables gram-scale preparation of (+)-chromazonarol. Subsequent synthetic operations on this key intermediate permit rapid access to a variety of related meroterpenoids, many of which possess important biological activity.

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