Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection.

Nanoscale
James HobsonSteve Rannard

Abstract

The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.

References

Jan 1, 1982·Critical Reviews in Food Science and Nutrition·H T Gordon, J C Bauernfeind
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Chang-Jer WuJohn T A Hsu
Sep 1, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cornelia M Keck, Rainer H Müller
Oct 4, 2005·International Journal of Pharmaceutics·Bharathi DevarakondaMelgardt M de Villiers
Nov 11, 2006·Pharmaceutical Research·Gilles DumortierJean Claude Chaumeil
Oct 30, 2007·Journal of Cataract and Refractive Surgery·Bradford J ShingletonMark W O'Donoghue
Jan 5, 2014·Advanced Drug Delivery Reviews·Elise LepeltierPatrick Couvreur
Sep 11, 2014·Drug Development and Industrial Pharmacy·Yanghuan YeBaojian Wu
Feb 25, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Liuqin LiangHanshi Xu
Sep 11, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Florence MorinFrédéric Batteux
Jan 24, 2018·Nature Communications·Rahul P BakshiTheresa A Shapiro
Jun 5, 2018·Drug Development and Industrial Pharmacy·Bindhu Madhavi RayaproluGopal Anyarambhatla
Jul 6, 2018·Food & Function·Felipe RochaOdinei Hess Gonçalves
Dec 28, 2019·Children·Christina KriegelGeorg Schmitt
Jun 10, 2020·Cytokine & Growth Factor Reviews·Víctor J Costela-RuizLucia Melguizo-Rodríguez
Nov 3, 2020·Journal of Ophthalmology·Monali S Malvankar-MehtaCindy Hutnik
Nov 21, 2020·British Journal of Clinical Pharmacology·Steven P RannardAndrew Owen
Jan 21, 2021·BioRxiv : the Preprint Server for Biology·Usman ArshadAndrew Owen

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