Mar 23, 2020

Scalable Surrogate Deconvolution for Identification of Partially-Observable Systems and Brain Modeling

BioRxiv : the Preprint Server for Biology
Matthew F SinghS. Ching


For many biophysical systems, direct measurement of all state-variables, in - vivo is not-feasible. Thus, a key challenge in biological modeling and signal processing is to reconstruct the activity and structure of interesting biological systems from indirect measurements. These measurements are often generated by approximately linear time-invariant (LTI) dynamical interactions with the hidden system and may therefore be described as a convolution of hidden state-variables with an unknown kernel. In the current work, we present an approach termed surrogate deconvolution, to directly identify such coupled systems (i.e. parameterize models). Surrogate deconvolution reframes certain nonlinear partially-observable identification problems, which are common in neuroscience/biology, as analytical objectives that are compatible with almost any user-chosen optimization procedure. We show that the proposed technique is highly scalable, low in computational complexity, and performs competitively with the current gold-standard in partially-observable system estimation: the joint Kalman Filters (Unscented and Extended). We show the benefits of surrogate deconvolution for model identification when applied to simulations of the Local Field Po...Continue Reading

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