PMID: 22572181Jan 1, 2010Paper

Scale and tooth phenotypes in medaka with a mutated ectodysplasin-A receptor: implications for the evolutionary origin of oral and pharyngeal teeth

Archives of Histology and Cytology
A D S AtukoralaYoshiro Takano

Abstract

Ectodermal contribution to the induction of pharyngeal teeth that form in the endodermal territory of the oropharyngeal cavity in some teleost fishes has been a matter of considerable debate. To determine the role of ectodermal cell signaling in scale and tooth formation and thereby to gain insights in evolutionary origin of teeth, we analyzed scales and teeth in rs-3 medaka mutants characterized by reduced scale numbers due to aberrant splicing of the ectodysplasin-A receptor (edar). Current data show that, in addition to a loss of scales (83% reduction), a drastic loss of teeth occurred in both oral (43.5% reduction) and pharyngeal (73.5% reduction) dentitions in rs-3. The remaining scales of rs-3 were irregular in shape and nearly 3 times larger in size relative to those of the wild-type. In contrast, there was no abnormality in size and shape in the remaining teeth of rs-3. In wild-type medaka embryos, there was a direct contact between the surface ectoderm and rostral endoderm in pharyngeal regions before the onset of pharyngeal tooth formation. However, there was no sign of ectodermal cell migration in the pharyngeal endoderm and hence no direct evidence of any ectodermal contribution to pharyngeal odontogenesis. These da...Continue Reading

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Citations

Sep 28, 2013·Trends in Genetics : TIG·Alexa SadierVincent Laudet
Feb 18, 2015·Connective Tissue Research·Bart Bruneel, Paul Eckhard Witten
Mar 4, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yuuki IidaAkira Kudo
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May 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Veronika OralováAnn Huysseune
Jul 29, 2020·Science China. Life Sciences·Yaoguo LiJun Zou
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Oct 15, 2021·Biological Reviews of the Cambridge Philosophical Society·Ann HuysseuneP Eckhard Witten

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